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A4980

Sigma-Aldrich

Abz-FRK(Dnp)P-OH trifluoroacetate salt

≥95% (HPLC), film

Sinônimo(s):

o-Aminobenzoic acid-FRK(Dnp)P-OH, o-aminobenzoic acid-Phe-Arg-Lys(DNP)-Pro-OH trifluoroacetate salt, Abz-Phe-Arg-Lys(DNP)-Pro-OH

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About This Item

Fórmula empírica (Notação de Hill):
C39H49N11O10 · xC2HF3O2
Peso molecular:
831.87 (free base basis)
Código UNSPSC:
12352200
NACRES:
NA.77

Ensaio

≥95% (HPLC)

forma

film

cor

yellow

temperatura de armazenamento

2-8°C

Amino Acid Sequence

Abz-Phe-Arg-Lys-DNP-Pro

Aplicação

Abz-FRK(Dnp)P-OH trifluoroacetate (TFA) is a substrate for the Angiotensin Converting Enzyme (ACE). Abz-FRK(Dnp)P-OH TFA has been used to study both the reduction of mortality of patients with sepsis and paracetamol-induced hypothermia.

Ações bioquímicas/fisiológicas

Substrate for ACE (Angiotensin Converting Enzyme). Internally quenched fluorogenic substrate for Real Time Fluorescent Assay.

Características e benefícios

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Jérémie Neasta et al.
British journal of pharmacology, 173(8), 1314-1328 (2016-03-31)
Using an in-house bioinformatics programme, we identified and synthesized a novel nonapeptide, H-Pro-Pro-Thr-Thr-Thr-Lys-Phe-Ala-Ala-OH. Here, we have studied its biological activity, in vitro and in vivo, and have identified its target in the brain. The affinity of the peptide was characterized
Wen Yang et al.
The Journal of pharmacology and experimental therapeutics, 339(3), 832-841 (2011-08-30)
Treatment with statins, inhibitors of HMG-CoA reductase, extends the survival of septic mice. However, the molecular mechanisms underlying the cholesterol-lowering, independent beneficial effects of statins in sepsis are poorly understood. The inhibition of protein isoprenylation, namely farnesylation and geranylgeranylation, has
M C Araujo et al.
Biochemistry, 39(29), 8519-8525 (2000-07-29)
Quenched fluorescence peptides were used to investigate the substrate specificity requirements for recombinant wild-type angiotensin I-converting enzyme (ACE) and two full-length mutants bearing a single functional active site (N- or C-domain). We assayed two series of bradykinin-related peptides flanked by
Maria Fernanda de M Costa et al.
Journal of veterinary science, 12(1), 21-25 (2011-03-04)
Angiotensin-I converting enzyme (ACE) is a key regulator of blood pressure, electrolytes and fluid homeostasis through conversion of angiotensin I into angiotensin II. Recently, a genetic polymorphism of the ACE gene, which accounts for 47% of the variation of ACE
Arnau Hervera et al.
Molecular pain, 7, 25-25 (2011-04-14)
The local administration of μ-opioid receptor (MOR) agonists attenuates neuropathic pain but the precise mechanism implicated in this effect is not completely elucidated. We investigated if nitric oxide synthesized by neuronal (NOS1) or inducible (NOS2) nitric oxide synthases could modulate
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