A0987

n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate

≥98% (HPLC)

• Sinônimo(s): Cytosporone A n-amyl ester, compound 10i
• Fórmula empírica (Notação de Hill): C₂₂H₃₄O₅
• Número CAS: 1257228-26-4
• Peso molecular: 378.50
• Número MDL: MFCD18632550
• Código UNSPSC: 12352200
• ID de substância PubChem: 329770645
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white
• solubilidade: DMSO: >65 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCCCCCCCC(=O)c1c(O)cc(O)cc1CC(=O)OCCCCC
• InChI: 1S/C22H34O5/c1-3-5-7-8-9-10-12-19(24)22-17(14-18(23)16-20(22)25)15-21(26)27-13-11-6-4-2/h14,16,23,25H,3-13,15H2,1-2H3
• chave InChI: FCKDHZVFIMRCNM-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate is a Nur77 agonist. Nur77 is a steroid orphan receptor that plays a critical role in regulating proliferation, differentiation and apoptosis. n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate, a cytosporone B analog, is a stronger activator of Nur77 than it parent compound. n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate treatment causes Nur77 migration to mitochondria, which results in mitochondrial Cyt c release into the cytoplasm and mitochondrial AIF redistribution in both the cytoplasm and nucleus.

Características e benefícios

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable