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Documentos

A0862

Sigma-Aldrich

A-740003

≥98% (HPLC)

Sinônimo(s):

N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide

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About This Item

Fórmula empírica (Notação de Hill):
C26H30N6O3
Número CAS:
861393-28-4
Peso molecular:
474.55
Número MDL:
MFCD09970333
Código UNSPSC:
12352200
ID de substância PubChem:
329770637
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to light brown

solubilidade

DMSO: 10 mg/mL, clear (warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1ccc(CC(=O)NC(N\C(Nc2cccc3ncccc23)=N\C#N)C(C)(C)C)cc1OC

InChI

1S/C26H30N6O3/c1-26(2,3)24(31-23(33)15-17-11-12-21(34-4)22(14-17)35-5)32-25(29-16-27)30-20-10-6-9-19-18(20)8-7-13-28-19/h6-14,24H,15H2,1-5H3,(H,31,33)(H2,29,30,32)

chave InChI

PUHSRMSFDASMAE-UHFFFAOYSA-N

Descrição geral

A-740003 is a highly affine and selective P2X7 receptor antagonist and is best for the progression of a radiotracer for imaging of neuroinflammation by positron emission tomography.

Ações bioquímicas/fisiológicas

A-740003 is a selective P2X7 purinoceptor antagonist.

Características e benefícios

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Clenbuterol hydrochloride ≥95%

Sigma-Aldrich

C5423

Clenbuterol hydrochloride

Brilliant Blue G 250, for microscopy

Sigma-Aldrich

27815

Brilliant Blue G

Sodium palmitate ≥98.5%

Sigma-Aldrich

P9767

Sodium palmitate

Pablo J Sáez et al.
PloS one, 8(8), e71361-e71361 (2013-08-27)
Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation. Moreover, increasing evidence suggests that neuroinflammation plays a pivotal role in the development of Niemann-Pick type C (NPC) disease, an
Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C] A-740003 as a novel tracer of neuroinflammation
Janssen B, et al.
Journal of Labelled Compounds & Radiopharmaceuticals, 57(8), 509-516 (2014)
Melissa Crabbé et al.
Frontiers in neuroscience, 13, 799-799 (2019-08-17)
The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson's disease (PD). Recently, P2X7 imaging has become possible with [11C]JNJ-(54173)717. We investigated P2X7 availability, in comparison with availability of
Zihao Li et al.
Frontiers in cell and developmental biology, 9, 695041-695041 (2021-07-06)
Moderate-intensity exercise can help delay the development of osteoarthritis (OA). Previous studies have shown that the purinergic receptor P2X ligand gated ion channel 7 (P2X7) is involved in OA development and progression. To investigate the effect of exercise on P2X7

Artigos

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