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94956

Sigma-Aldrich

Vinylcyclohexene dioxide

purum, suitable for electron microscopy, mixture of isomers, ≥96.0% (GC)

Sinônimo(s):

4-vinyl-1-cyclohexene diepoxide, 1,2-Epoxy-4-epoxyethylcyclohexane, 3-Epoxyethyl-7-oxabicyclo[4.1.0]heptane

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100 ML
R$ 2.773,00
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About This Item

Fórmula empírica (Notação de Hill):
C8H12O2
Número CAS:
106-87-6
Peso molecular:
140.18
Beilstein:
106071
Número CE:
203-437-7
Número MDL:
MFCD00022354
Código UNSPSC:
12162002
ID de substância PubChem:
57653591
NACRES:
NA.25

R$ 2.773,00

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Nível de qualidade

100

grau

purum

Ensaio

≥96.0% (GC)

Formulário

liquid

técnica(s)

electron microscopy: suitable

índice de refração

n20/D 1.477 (lit.)
n20/D 1.479

p.e.

230-232 °C (lit.)

densidade

1.094 g/mL at 25 °C (lit.)

cadeia de caracteres SMILES

C1CC2OC2CC1C3CO3

InChI

1S/C8H12O2/c1-2-6-7(10-6)3-5(1)8-4-9-8/h5-8H,1-4H2

chave InChI

OECTYKWYRCHAKR-UHFFFAOYSA-N

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Aplicação

Vinylcyclohexene dioxide (VCD) may be used to study and understand its effect on ovarian follicles and effects on epithelial differentiation.

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Nº do produto
Descrição
Preços

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1B

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

224.6 °F - closed cup

Ponto de fulgor (°C)

107 °C - closed cup

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BCCM3213
BCCM5102
BCCJ4415
BCBW6333
BCBW2871

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Cyclohexene oxide 98%

Sigma-Aldrich

C102504

Cyclohexene oxide

Poulomi Bhattacharya et al.
Toxicology and applied pharmacology, 267(1), 49-56 (2013-01-01)
4-Vinylcyclohexene diepoxide (VCD) destroys ovarian primordial and small primary follicles via apoptosis. In mice, VCD exposure induces ovarian mRNA expression of glutathione S-transferase (GST) family members, including isoform mu (Gstm). Extra-ovarian GSTM negatively regulates pro-apoptotic apoptosis signal-regulating kinase 1 (ASK1)
Jazmin I Acosta et al.
Endocrinology, 150(9), 4248-4259 (2009-05-28)
Clinical research suggests that type of ovarian hormone loss at menopause influences cognition. Until recently ovariectomy (OVX) has been the primary rodent model to examine effects of ovarian hormone loss on cognition. This model limits evaluations to abrupt and complete
P B Hoyer et al.
Toxicologic pathology, 29(1), 91-99 (2001-02-24)
Female mammals are born with a finite number of ovarian primordial follicles that cannot be regenerated; thus, chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopuase in women). Exposure of women to known ovotoxicants
Connie J Mark-Kappeler et al.
Biology of reproduction, 85(4), 755-762 (2011-06-17)
In vitro exposure of Postnatal Day 4 (PND4) rat ovaries to the occupational chemical 4-vinylcyclohexene diepoxide (VCD) destroys specifically primordial and primary follicles via acceleration of atresia. Because oocyte-expressed c-kit (KIT) plays a critical role in follicle survival and activation
Laura A Laviolette et al.
Menopause (New York, N.Y.), 18(5), 549-557 (2011-01-12)
Ovarian cancer is often diagnosed in women after menopause when the levels of the serum gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are increased because of the depletion of growing follicles within the ovary. The ability of FSH and
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Questions

1–5 of 5 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How should VCD be stored, for short term and long term?

    1 answer

    1. This product may be stored at room temperature for both, short and long term periods.

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  4. What is the concentration of VCD #94956 ( mg / ml)?

    1 answer

    1. This product is supplied as a neat or pure liquid with a density of 1.094 g/mL and a molecular weight of 140.18 g/mol. The minimum purity is 96%, thus the molarity will vary slightly from lot to lot. The molarity can range from 7.5 M (96%) to 7.8 M (100%). The lot specific purity is reported on the Certificate of Analysis. Please see the link below to review a sample Certificate: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/94956-BULKBCCJ4415.pdf

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  5. ¿En qué está disuelto este producto (94956): aceite de sesamo, Alcohol, DMSO? . Tengo que usarlo más diluido para inyectar en ratones. Gracias

    1 answer

    1. Product 94956 is a neat liquid of Vinylcyclohexene dioxide (VCD) at room temperature. According to the following scientific article, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703138/, VCD was either prepared for intramuscular injection with cottonseed oil, or prepared with sesame oil for intraperitoneal injection.

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