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64382

Sigma-Aldrich

DL-Methionine methylsulfonium chloride

≥97.0% (AT)

Sinônimo(s):

(3-Amino-3-carboxypropyl)dimethyl sulfonium chloride, MMS, Methyl-methionine sulphonium chloride, Vitamin U

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About This Item

Fórmula empírica (Notação de Hill):
C6H14ClNO2S
Número CAS:
3493-12-7
Peso molecular:
199.70
Beilstein:
4163617
Número CE:
222-484-4
Número MDL:
MFCD00031700
Código UNSPSC:
12352209
ID de substância PubChem:
57651981
NACRES:
NA.26

fonte biológica

synthetic

Ensaio

≥97.0% (AT)

Formulário

powder

Impurezas

≤0.002% heavy metals

resíduo de ignição

≤0.1%

perda

≤3% loss on drying

cor

colorless to white

pH

4.0-5.5

pf

139-140 °C

solubilidade

H2O: 100 mg/mL, clear, colorless

cadeia de caracteres SMILES

[Cl-].C[S+](C)CCC(N)C(O)=O

InChI

1S/C6H13NO2S.ClH/c1-10(2)4-3-5(7)6(8)9;/h5H,3-4,7H2,1-2H3;1H

chave InChI

MYGVPKMVGSXPCQ-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

DL-Methionine methylsulfonium (DL-MMSC), a racemic mixture, is used to study its mechanism of protection against gastric ulceration. DL-MMSC may also be used as a methionine analogue.
S-Methionine methylsulfonium (SMMS) chloride is a derivative of methionine metabolism in some plants. SMMS has potent therapeutic effects on gastrointestinal ulceration potentially via its ability to promote dermal fibroblast migration and growth.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCCB2364
BCBZ8740
BCBZ3914
BCBX4610
BCBG6143V

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Takafumi Ichikawa et al.
Journal of gastroenterology and hepatology, 24(3), 488-492 (2009-01-30)
In Japan, peptic ulcer disease (PUD) is treated clinically with a combination of a mucosal protectant and acid suppressants, but there is scant information regarding the effects of these drugs on normal gastric mucus cells. In the present study, the
Effect of s-methylmethionine sulphonium chloride on oesophagogastric ulcers in pigs.
Kopinski JS, Fogarty R, McVeigh J.
Australian Journal of Chemistry, 85, 362-367 (2007)
Ji-Hoon Song et al.
Journal of food science, 82(1), 36-43 (2016-11-25)
The objectives of the current study were to determine S-methyl-L-methionine (SMM) from various Brassicaceae family vegetables by using validated analytical method and to characterize the intestinal transport mechanism of SMM by the Caco-2 cells. The SMM is well known to
A S Salim
Journal of pharmaceutical sciences, 81(7), 698-700 (1992-07-01)
Reserpine (intraperitoneal, 5 mg/kg every day for 5 days) produced chronic ulceration of the rat stomach 2 weeks postdose. Gavage with 1% DL-cysteine or DL-methionine-S-methylsulfonium chloride at 1 mL/day for 2 weeks and 5 days protected against ulceration in 30%
A S Salim
Pharmacology, 46(5), 281-288 (1993-05-01)
This prospective randomized double-blind controlled study investigated whether sulphydryl-containing agents protect against the recurrence of duodenal ulceration. To this end, DL-cysteine (200 mg 4 times daily) and DL-methionine-methyl sulphonium chloride (MMSC, 500 mg 4 times daily) were administered orally. Three
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