377M-1

Smoothelin (R4A) Mouse Monoclonal Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100; 500
• conjugado: unconjugated
• forma do anticorpo: diluted ascites fluid
• tipo de produto de anticorpo: primary antibodies
• clone: R4A, monoclonal
• descrição: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Formulário: buffered aqueous solution
• reatividade de espécies: human
• embalagem: vial of 0.1 mL concentrate (377M-14); vial of 0.5 mL concentrate (377M-15); bottle of 1.0 mL predilute (377M-17); vial of 1.0 mL concentrate (377M-16); bottle of 7.0 mL predilute (377M-18)
• fabricante/nome comercial: Cell Marque^®
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• Isotipo: IgG1
• controle: bladder, leiomyoma
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• visualização: cytoplasmic, nuclear
• Informações sobre genes: human ... SMTN(6525)

Descrição

Descrição geral

Smoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin.[1][2] To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task of staging bladder urothelial carcinoma, such as in transurethral resection specimens of urinary bladder tumors.[3][4][5][6][7][8] Differentiating between smooth muscle tumors and other mesenchymal neoplasms of the GI tract can be challenging in small biopsies. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics(-).[9]

Qualidade

IVD

IVD

IVD

RUO

Ligação

Smoothelin Positive Control Slides, Product No. 377S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

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Outras notas

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Informações legais

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany