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Merck
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259A-1

Sigma-Aldrich

Glucagon Rabbit Polyclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

Ig fraction of antiserum

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

forma

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (259A-14)
vial of 0.5 mL concentrate (259A-15)
bottle of 1.0 mL predilute (259A-17)
vial of 1.0 mL concentrate (259A-16)
bottle of 7.0 mL predilute (259A-18)

fabricante/nome comercial

Cell Marque

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

controle

pancreas

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

cytoplasmic

Informações sobre genes

human ... GCG(2641)

Descrição geral

The normal islets of Langerhans (pancreas) contain four major cell types, 15-20% of which are alpha cells which produce glucagon. Alpha cell tumors can be divided into two distinct types; those associated with glucagonoma syndrome (necrolytic migratory erythema, diabetes, anemia, stomatitis, weight loss, venous thromboses, diarrhea, and sometimes psychiatric disturbances), and those which are not. Those associated with the syndrome tend to be large and solitary and there is a high incidence of malignancy. Those glucagonomas not associated with the syndrome tend to be multiple and small and are nearly always benign.Immunohistochemically, the two types of glucagonoma are reactive to the glucagon antibody, though occasionally only weakly.

Qualidade


IVD

IVD

IVD

RUO

Ligação

Glucagon (polyclonal) Positive Control Slides, Product No. 259S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Aixia Sun et al.
Transplantation direct, 10(7), e1658-e1658 (2024-06-17)
Transplantation of human-induced pluripotent stem cell (hiPSC)-derived islet organoids is a promising cell replacement therapy for type 1 diabetes (T1D). It is important to improve the efficacy of islet organoids transplantation by identifying new transplantation sites with high vascularization and
Rosai and Ackerman's Surgical Pathology, 10th ed., 1030-1031 (2011)
Diagnostic Immunohistochemistry: Theranostic and Genomic Applications (2010)
Q A Hamid et al.
Histopathology, 10(2), 119-133 (1986-02-01)
Histological diagnosis of neuroendocrine tumours can be hampered by their lack of peptide or amine immunoreactivity. In order to assess the usefulness of a range of specific and general markers of neuroendocrine differentiation, 10 pancreatic endocrine tumours, associated with high
Yang Xiao et al.
Diabetologia, 66(6), 1142-1155 (2023-03-15)
Glucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies suggest that TGF-β is able to promote hepatic gluconeogenesis in mice. However, the physiological relevance of serum TGF-β levels to human glucose metabolism and the mechanism by which

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