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Y0000757

(−)-Riboflavina

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

Lactoflavina, Vitamina B2, Vitamina G

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About This Item

Fórmula empírica (Notação de Hill):
C17H20N4O6
Número CAS:
83-88-5
Peso molecular:
376.36
Beilstein:
97825
Número MDL:
MFCD00005022
Código UNSPSC:
41116107
ID de substância PubChem:
329831131
NACRES:
NA.24
Preço e disponibilidade não estão disponíveis no momento.

fonte biológica

synthetic

grau

pharmaceutical primary standard

Agency

EP

família API

riboflavin

Formulário

solid

fabricante/nome comercial

EDQM

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

pf

290 °C (dec.) (lit.)

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1

InChI

1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1

chave InChI

AUNGANRZJHBGPY-SCRDCRAPSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Riboflavin, also known as vitamin B2, is crucial for human nutrition, and growth. It finds potential applications in biological redox reactions and is found in several foodstuffs, energy drinks, and vitamin formulations.[1][2]

Aplicação

Riboflavin may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.[3]

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

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Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Riboflavin Impurity A Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1936

Riboflavin Impurity A

Riboflavin Sodium Phosphate Hydrate tested according to Ph. Eur.

Sigma-Aldrich

77623

Riboflavin Sodium Phosphate Hydrate

Lumichrome

Sigma-Aldrich

103217

Lumichrome

Riboflavin 5′-phosphate sodium salt hydrate meets USP testing specifications

Sigma-Aldrich

R7774

Riboflavin 5′-phosphate sodium salt hydrate

Riboflavin
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 5(2), 3484-3485 (2008)
Differential pulse polarographic method development and validation of riboflavin in pharmaceutical formulation
Kashid LM and Patil SV
International Journal of Scientific Research, 5(2), 325-334 (2015)
Simultaneous determination of riboflavin phosphate and other ingredients in a multivitamin pharmaceutical preparation by on-line automated LC coupled with pre-column immobilized enzyme reactor
Ono M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(1-2), 325-334 (2002)
Olivier Richoz et al.
Investigative ophthalmology & visual science, 55(9), 5783-5787 (2014-07-24)
When treating peripheral ectatic disease-like pellucid marginal degeneration (PMD), corneal cross-linking with UV-A and riboflavin (CXL) must be applied eccentrically to the periphery of the lower cornea, partly irradiating the corneal limbus. Here, we investigated the effect of standard and
Frederik Raiskup et al.
The ocular surface, 11(2), 65-74 (2013-04-16)
Changes in the biomechanical properties of the human cornea play an important role in the pathogenesis of corneal ectatic diseases. Biomechanical investigation shows significant differences between human ectatic corneas and normal corneas, including decreased stiffness and reduction of collagen crosslinks
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