R9504

(−)-Riboflavina

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

• Sinônimo(s): Lactoflavina, Vitamina B₂, Vitamina G
• Fórmula empírica (Notação de Hill): C₁₇H₂₀N₄O₆
• Número CAS: 83-88-5
• Peso molecular: 376.36
• Beilstein: 97825
• Número CE: 201-507-1
• Número MDL: MFCD00005022
• Código UNSPSC: 12352205
• eCl@ss: 34058005
• ID de substância PubChem: 24899415
• NACRES: NA.75

Propriedades

• fonte biológica: Eremothecium ashbyii
• linha de produto: BioReagent
• Ensaio: ≥98%
• forma: powder
• peso molecular: M_w 376.36 g/mol
• técnica(s): cell culture | insect: suitable; cell culture | mammalian: suitable
• cor: yellow to orange
• pf: 290 °C (dec.) (lit.)
• solubilidade: 0.1 M NaOH: 10 mg/mL, clear, yellow to orange
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1
• InChI: 1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1
• chave InChI: AUNGANRZJHBGPY-SCRDCRAPSA-N

Descrição

Descrição geral

Riboflavin supports cell growth and metabolism, aiding researchers in R&D. In cell culture, it is often found as a key ingredient in media formulations. Cancer researchers study its impact on oxidative stress responses. Stem cell researchers value its role in maintaining pluripotency.


Riboflavin is an essential vitamin soluble in water. Milk and eggs are found to be its major sources. Riboflavin is usually bound to enzymes in all tissues. During riboflavin localization in plasma, it is bound to albumin and specific immunoglobulins.

Aplicação

(-)-Riboflavin has been used to administer intraperitoneally to experimental mice to study its protective role in stroke in middle cerebral artery occlusion. It has also been used with Krebs′ solution, to model ischemia-like conditions in vitro.

Ações bioquímicas/fisiológicas

Riboflavin serves as a precursor for the active enzyme cofactors riboflavin 5′-monophosphate (also called flavin mononucleotide or FMN) and flavin adenine dinucleotide (FAD). Riboflavin deficiency in the diet results in a well-defined syndrome known as ariboflavinosis, having symptoms including cheilosis, angular stomatitis, glossitis, keratitis, and seborrhoeic dermatitis. Riboflavin exhibits protective effects against tumor development and cardiovascular disease. Its deficiency often affects metabolism involving redox reactions. Riboflavin is found essential for iron absorption, gastrointestinal development, neurogenesis, corneal vascularization and corneal opacity.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)