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S0883

Sigma-Aldrich

Sulfasalazine

97.0-101.5%

Sinônimo(s):

2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid, 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, Salicylazosulfapyridine

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About This Item

Fórmula empírica (Notação de Hill):
C18H14N4O5S
Número CAS:
599-79-1
Peso molecular:
398.39
Beilstein:
356241
Número CE:
209-974-3
Número MDL:
MFCD00057363
Código UNSPSC:
41116107
ID de substância PubChem:
329824182
NACRES:
NA.24

Nível de qualidade

200

Ensaio

97.0-101.5%

forma

powder

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

pf

260-265 °C (dec.) (lit.)

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)

Modo de ação

DNA synthesis | interferes
enzyme | inhibits

cadeia de caracteres SMILES

OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3

InChI

1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+

chave InChI

NCEXYHBECQHGNR-QZQOTICOSA-N

Informações sobre genes

human ... ALOX5(240) , PTGS1(5742) , PTGS2(5743)

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Categorias relacionadas

Descrição geral

Chemical structure: sulfonamide
Sulfasalazine (SSZ) belongs to the sulfonamide class of drugs, which can be metabolized into 5-aminosalicylic acid and sulfapyridine. SSZ is obtained as a reaction product of an antibacterial agent (sulfapyridine) and an anti-inflammatory agent (salicylic acid).

Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfasalazine has been used as an analytical standard in clinical studies:
  • For investigating its therapeutic potential in patients suffering from multiple sclerosis (MS).
  • For studying its role as an antiarthritic agent via inhibition of the cartilage degeneration and pain associated with progression of osteoarthritis in the rat, which is used as the test animal.

It may also be used as an analytical reference standard for the quantification of the analyte in biological samples and aqueous samples using enzyme-linked immunosorbent assay (ELISA) and spectrofluorimetic technique.



Pictogramas

Health hazardEnvironment
GHS08,GHS09

Palavra indicadora

Danger

Classificações de perigo

Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificados de análise (COA)

Lot/Batch Number
0000322548
0000310553
0000336876
0000227395
0000278622

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Sigma-Aldrich

549835

2,4,6-Tris(dimethylamino)-1,3,5-triazine

Mesalazine British Pharmacopoeia (BP) Reference Standard

BP1075

Mesalazine

Maarten Boers et al.
Annals of the rheumatic diseases, 72(3), 406-409 (2012-11-17)
Treatment of rheumatoid arthritis (RA) with tumour necrosis factor (TNF) antagonists changes the relationship between disease activity and progression of radiological joint damage ('disconnect'): patients who have little or no response of disease activity still show reductions in damage progression.
A solid-phase luminescence sensor based on molecularly imprinted polymerCdSeS/ZnS quantum dots for selective extraction and detection of sulfasalazine in biological samples
Ahmadpour H, et al.
Talanta, 194, 534-541 (2019)
Immunochemical method for sulfasalazine determination in human plasma
Pastor-Navarro N, et al.
Analytica Chimica Acta, 583(2), 377-383 (2007)
Johan A Karlsson et al.
Annals of the rheumatic diseases, 72(12), 1927-1933 (2012-12-01)
To compare EuroQol 5-Dimensions (EQ-5D) utility and quality-adjusted life-years (QALYs) in patients with early, methotrexate (MTX) refractory rheumatoid arthritis (RA), randomised to addition of infliximab (IFX) or sulfasalazine and hydroxychloroquine (SSZ+HCQ). RA-patients with symptoms <1 year were enrolled between 2002
M van den Broek et al.
Clinical and experimental rheumatology, 30(4 Suppl 73), S35-S38 (2012-10-20)
Targeted treatment is effective in the short term in achieving low disease activity or even remission in patients with rheumatoid arthritis (RA). The benefits of long-term targeted treatment are discussed based on the BeSt study results. The BeSt study has
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