PHR1331
Metformin Related Compound A
Pharmaceutical Secondary Standard; Certified Reference Material
Sinônimo(s):
Dicyandiamide, Cyanoguanidine, Dicyanodiamide
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About This Item
Fórmula linear:
NH2C(=NH)NHCN
Número CAS:
Peso molecular:
84.08
Beilstein:
605637
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24
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certified reference material
pharmaceutical secondary standard
Nível de qualidade
Agency
traceable to USP 1396310
família API
metformin
Certificado de análise (CofA)
current certificate can be downloaded
técnica(s)
HPLC: suitable
gas chromatography (GC): suitable
pf
208-211 °C (lit.)
aplicação(ões)
pharmaceutical (small molecule)
formato
neat
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
NC(=N)NC#N
InChI
1S/C2H4N4/c3-1-6-2(4)5/h(H4,4,5,6)
chave InChI
QGBSISYHAICWAH-UHFFFAOYSA-N
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Descrição geral
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the widely used antidiabetic drug, metformin, that belongs to the biguanide class of compounds.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the widely used antidiabetic drug, metformin, that belongs to the biguanide class of compounds.
Aplicação
This pharmaceutical secondary standard can also be used as follows:
- Separation and estimation of metformin along with other antidiabetics from meglitinides class in the presence of metformin impurity cyanoguanidine using a liquid chromatography method in pharmaceutical formulations
- Development of a reversed phase-high performance liquid chromatographic (RP-HPLC) method combined with a UV-diode array detector (PDA) for the impurity analysis of combined dosage tablet of metformin hydrochloride and teneligliptin hydrobromide hydrate
- Estimation of empagliflozin, linagliptin, along with metformin and its related impurities cyanoguanidine and melamine using HPLC-DAD and high-performance thin layer chromatography (HPTLC) methods in their combined tablets
- Development and validation of a stability indicating capillary zone electrophoresis (CZE) method for the quantification of metformin and its major impurity in pharmaceutical formulation
- Simultaneous determination of vildagliptin, metformin, and metformin-related compounds (A, B, and C) in tablets using a high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS)
Nota de análise
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Nota de rodapé
To see an example of a Certificate of Analysis for this material enter LRAA0834 in the slot below. This is an example certificate only and may not be the lot that you receive.
produto relacionado
Nº do produto
Descrição
Preços
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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HPLC-MS/MS method for simultaneous quantification of vildagliptin, metformin, and metformin-related compounds in tablets
Uber CP, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 6, 203-207 (2014)
Green chromatographic methods for simultaneous micro-determination of empagliflozin, linagliptin with metformin and its pharmacopoeial impurities in pure form and triple combination tablets: A comparative study
El-Kafrawy DS, et al.
Sustainable Chemistry and Pharmacy, 25, 100560-100560 (2022)
A new rapid and economic liquid chromatographic method for simultaneous determination of meglitinides with metformin: application in the presence of metformin and repaglinide impurities and related compounds
El-Zaher AA, et al.
Journal of the Iranian Chemical Society, 15, 61-74 (2018)
Impurity profiling method development and validation of metformin hydrochloride and teneligliptin hydrobromide hydrate in their combination tablet dosage form by using RP-HPLC with UV/PDA detector
Musmade BD, et al.
Future Journal of Pharmaceutical Sciences, 7, 1-10 (2021)
Changkyu Kim et al.
Nanoscale, 7(15), 6627-6635 (2015-03-21)
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