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PHR1303

Supelco

3,4,4` Trichlorocarbanilide (Triclocarban)

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

3,4,4′-Trichlorocarbanilide, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea, TCC, Triclocarban

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About This Item

Fórmula linear:
Cl2C6H3NHCONHC6H4Cl
Número CAS:
101-20-2
Peso molecular:
315.58
Número MDL:
MFCD00013254
Código UNSPSC:
41116107
ID de substância PubChem:
329823291
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

300

pressão de vapor

<0.1 mmHg ( 25 °C)

família API

triclocarban

Certificado de análise (CofA)

current certificate can be downloaded

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

pf

254-256 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1

InChI

1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19)

chave InChI

ICUTUKXCWQYESQ-UHFFFAOYSA-N

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Descrição geral

3,4,4′-Trichlorocarbanilide (Triclocarban) is an ester of 3,4,4′-trichlorocarbanilide and belongs to the group of endocrine disruptors. It is widely used as a preservative and bactericide in a variety of personal care products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA0063 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Environment
GHS09

Palavra indicadora

Warning

Frases de perigo

H410

Declarações de precaução

P273 - P501

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

>302.0 °F

Ponto de fulgor (°C)

> 150 °C

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Certificados de análise (COA)

Lot/Batch Number

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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

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Xiaoliu Zhou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 881-882, 27-33 (2011-12-24)
3,4,4'-Trichlorocarbanilide (triclocarban, TCC) is widely used as an antimicrobial agent in a variety of consumer and personal care products. Because of its widespread use, the potential for human exposure to TCC is high. Human exposure to TCC may be assessed
Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry
Gonzalez-Marino I, et al.
Rapid Communications in Mass Spectrometry, 23(12), 1756-1766 (2009)
Arjun K Venkatesan et al.
Journal of hazardous materials, 229-230, 29-35 (2012-06-30)
The antimicrobial agents triclosan (TCS), triclocarban (TCC) and their associated transformation products are of increasing concern as environmental pollutants due to their potential adverse effects on humans and wildlife, including bioaccumulation and endocrine-disrupting activity. Analysis by tandem mass spectrometry of
Jian-Liang Zhao et al.
Water research, 47(1), 395-405 (2012-11-07)
Triclosan (TCS) and triclocarban (TCC) are two commonly used personal care products. They may enter into aquatic environments after consumption and pose potential risks to aquatic organisms. We investigated the occurrence and fate of TCS and TCC in five large
F Gressier et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(1), 35-42 (2014-07-23)
The cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of most antidepressants. Comedication with a potent CYP2D6 inhibitor can convert patients with extensive metabolizer (EM) or ultra-rapid metabolizer (UM) genotypes into poor metabolizer (PM) phenotypes. Since comedication is frequent
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