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H7753

Supelco

Hexestrol

analytical standard

Sinônimo(s):

4,4′-(1,2-Diethylethylene)diphenol, meso-3,4-Bis(4-hydroxyphenyl)hexane, Dihydrodiethylstilbestrol

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About This Item

Fórmula empírica (Notação de Hill):
C18H22O2
Número CAS:
84-16-2
Peso molecular:
270.37
Beilstein:
3209460
Número CE:
201-518-1
Número MDL:
MFCD00068996
Código UNSPSC:
41116107
ID de substância PubChem:
329815246
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

100

Ensaio

≥98%

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Formato

neat

cadeia de caracteres SMILES

CC[C@H]([C@H](CC)c1ccc(O)cc1)c2ccc(O)cc2

InChI

1S/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3/t17-,18+

chave InChI

PBBGSZCBWVPOOL-HDICACEKSA-N

Informações sobre genes

human ... ESR1(2099)
rat ... Esr1(24890)

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Descrição geral

Hexestrol is a synthetic nonsteroidal estrogen,[1] which can be used in human medicine as well as a growth promoter in cattle.[2]

Aplicação

Hexestrol may be used as a reference standard for the determination of the analyte in biological samples using immunoaffinity extraction and gas chromatography-negative-ion chemical ionization mass spectrometry.[2]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ações bioquímicas/fisiológicas

The carcinogen hexestrol is a nonsteroidal synthetic estrogen. Metabolic activation of hexestrol to its quinone, which reacts with DNA to form analogous depurinating adducts, may be a primary critical event leading to oncogenic mutations and cancer initiation.

Ligação

Reduced analogue of diethylstilbestrol.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H350

Classificações de perigo

Carc. 1B

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 2

Equipamento de proteção individual

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
MKCM4126
MKCK7639
MKCK4408
MKCH4229
MKCC7215

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

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Muhammad Saeed et al.
Steroids, 70(1), 37-45 (2004-12-22)
The nonsteroidal synthetic estrogen hexestrol (HES), which is diethylstilbestrol hydrogenated at the C-3-C-4 double bond, is carcinogenic. Its major metabolite is the catechol, 3'-OH-HES, which can be metabolically converted to the catechol quinone, HES-3',4'-Q. Study of HES was undertaken with
Weixuan Lin et al.
Se pu = Chinese journal of chromatography, 27(3), 294-298 (2009-10-07)
A method of gas chromatography-mass spectrometry (GC-MS) for the simultaneous determination of nine sex hormone residues, such as hexestrol, diethylstilbestrol, dienestrol, etiocholan-3alpha-ol-17-one, epitestosterone, estrone, estradiol, ethinylestradiol and estriol, in animal tissues was developed. The sex hormones were extracted with acetonitrile
A R Pop et al.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 52(1 Suppl), 413-417 (2011-04-01)
The research was performed on 24 male sexually mature domestic rabbits, divided in two equal batches. The rabbits from the first batch were administered 0.5 mg/kg of body weight hexestrol diacetate intramuscularly twice a week for four consecutive weeks. Batch
Karol L Thompson et al.
International journal of toxicology, 31(1), 14-24 (2012-01-24)
Cationic amphiphilic drugs and aminoglycoside antibiotics can induce phospholipidosis (PLD), an abnormal accumulation of phospholipids in lysosome-derived vesicles, in preclinical studies. The incidence of PLD in patients and its clinical relevance are difficult to assess without noninvasive biomarkers. Di-docosahexaenoyl bis(monoacylglycerol)phosphate
R Todd Stravitz et al.
Clinics in liver disease, 7(2), 435-451 (2003-07-26)
Drugs rarely cause steatohepatitis, but amiodarone, perhexiline, and DH, have unequivocally been found to independently induce the histologic picture of alcoholic liver disease or NASH. All three agents have similar pathogenetic mechanisms of hepatotoxicity, targeting mitochondrial ATP production and fatty
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