Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
D2975000
Doxorrubicina
European Pharmacopoeia (EP) Reference Standard
Sinônimo(s):
DOX, Hidroxidaunorrubicina
About This Item
Produtos recomendados
grau
pharmaceutical primary standard
família API
doxorubicin
fabricante/nome comercial
EDQM
pf
216 °C (dec.) (lit.)
aplicação(ões)
pharmaceutical (small molecule)
Formato
neat
cadeia de caracteres SMILES
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
chave InChI
MWWSFMDVAYGXBV-RUELKSSGSA-N
Informações sobre genes
human ... TOP2A(7153)
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Descrição geral
For further information and support please go to the website of the issuing Pharmacopoeia.
Produced by certain strains of Streptomyces coeruleorubidus or Streptomyces peucetius or obtained by any other means.
Aplicação
Established for the preparation of the below-given solutions as per European Pharmacopoeia:
- Reference solutions (b) and (c) in the testing of related substances in daunorubicin hydrochloride using liquid chromatography (General text 2.2.29), according to the monograph 0662
- Reference solutions (a) and (c) to test related substances in doxorubicin hydrochloride using liquid chromatography (General text 2.2.29), according to the monograph 0714
- Reference solutions (b) and (c) in the testing of related substances in epirubicin hydrochloride using liquid chromatography (General text 2.2.29), according to the monograph 1590
Embalagem
Outras notas
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Certificados de análise (COA)
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How is shipping temperature determined? And how is it related to the product storage temperature?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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può gentilmente dirmi se questo prodotto si può utilizzare per esperimenti sul topo?
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This product is intended for use as an analytical standard and has not been tested for use in other applications. Currently, there is no Doxorubicin HCl product available that has been tested for in vivo or in vitro use. However, the research grade item, D1515, has been used successfully in mice, as cited in several publications. Please see the links below to review articles that may be of interest:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451836/pdf/PAN_2020_v24n2_11.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036477/Helpful?
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