If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
PHR1789
Doxorrubicina
Pharmaceutical Secondary Standard; Certified Reference Material
Sinônimo(s):
DOX, Hidroxidaunorrubicina
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About This Item
grau
certified reference material
pharmaceutical secondary standard
Nível de qualidade
Agency
traceable to BP 990
traceable to Ph. Eur. D2975000
traceable to USP 1225703
família API
doxorubicin
Formulário
powder
Certificado de análise (CofA)
current certificate can be downloaded
embalagem
pkg of 200 mg
técnica(s)
HPLC: suitable
gas chromatography (GC): suitable
pf
216 °C (dec.) (lit.)
aplicação(ões)
pharmaceutical (small molecule)
temperatura de armazenamento
-10 to -25°C
cadeia de caracteres SMILES
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
chave InChI
MWWSFMDVAYGXBV-RUELKSSGSA-N
Informações sobre genes
human ... TOP2A(7153)
Procurando produtos similares? Visita Guia de comparação de produtos
Descrição geral
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.
Aplicação
- Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples[1]
- Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe2O4) modified carbon paste electrode in biological fluid and injection samples[2]
- Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
- RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations[3]
- Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples[4]
Nota de análise
Nota de rodapé
Produtos recomendados
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Certificados de análise (COA)
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
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How should the doxorubicin be dissolved? I have seen DMSO, but what is the optimal solution to dilute the DMSO and at what percentage?
1 answer-
This product is not tested for solubility. However, information available for other Doxorubicin HCl products will apply.
D1515, Doxorubicin HCl, is soluble in water and pure DMSO at 50 mg/ml.
Solutions are sensitive to light and will degrade over long-term exposure.
https://www.sigmaaldrich.com/product/sigma/d1515D5225, Doxorubicin, Ready-Made solution is a 2mg/ml solution in pure DMSO.
The product is stored at 20°C and is assigned a retest schedule of every 2 years.
https://www.sigmaaldrich.com/product/sigma/d5220Solutions appear to be reasonably stable when protected from light.
See the link below to review a publication regarding the solution stability of Doxorubicin HCl.:
https://pubmed.ncbi.nlm.nih.gov/517541/Helpful?
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