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C0400000

Calcium pantothenate

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

D-Pantothenic acid hemicalcium salt, (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B5

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About This Item

Fórmula linear:
HOCH2C(CH3)2CH(OH)CONHCH2CH2CO2 ·1/2Ca
Número CAS:
Peso molecular:
238.27
Beilstein:
3769272
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

fonte biológica

synthetic

grau

pharmaceutical primary standard

Agency

EP

família API

calcium pantothenate

forma

solid

fabricante/nome comercial

EDQM

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

InChI

1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1

chave InChI

FAPWYRCQGJNNSJ-UBKPKTQASA-L

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Calcium pantothenate, the calcium salt of pantothenic acid, is a coenzyme A component that plays an important role in the metabolism of proteins, fats and carbohydrates. It is employed in vitamin supplements for the treatment of acne, osteoarthritis, rheumatoid arthritis, etc.

Aplicação

Calcium pantothenate may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and spectrophotometric techniques.
Precursor in the biosynthesis of coenzyme A.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

propriedades físicas

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

Outras notas

Sales restrictions may apply.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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HPLC determination of calcium pantothenate and two preservatives in topical cream
Havlikova L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(2), 671-675 (2006)
Calcium pantothenate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3, 6881-6882 (2019)
Vademecum for Vitamin Formulations (2001)
A reverse phase HPLC assay for the determination of calcium pantothenate utilizing column switching
Franks TJ and Stodola JD
Journal of Liquid Chromatography, 7(4), 823-837 (1984)
Simultaneous estimation of ascorbic acid and calcium pantothenate in: Multivitamin and multimineral tablets by reverse-phase HPLC
Dudhwal R, et al.
Der Pharm Chem, 3, 357-381 (2011)

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