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ALD00604

Sigma-Aldrich

(+)-PSI Reagent

95%

Sinônimo(s):

(+)-Ψ, (2R,3aR,6S,7aR)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, Phosphorus-Sulfur Incorporation Reagent

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About This Item

Fórmula empírica (Notação de Hill):
C16H16F5OPS3
Número CAS:
2245335-71-9
Peso molecular:
446.46
Código UNSPSC:
12352101
NACRES:
NA.22

Ensaio

95%

forma

powder or crystals

pf

102-107 °C

Categorias relacionadas

Aplicação

Air- and moisture-tolerant, this (+)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (−)-PSI Reagent, is also available (cat# ALD00602).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Outras notas

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

PSI on OpenFlask

Informações legais

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

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Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Choose from one of the most recent versions:

Certificados de análise (COA)

Lot/Batch Number
MKCT4944
MKCN8643
MKCM6673
MKCM1315
MKCK1966

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Science (New York, N.Y.), 361(6408), 1234-1238 (2018-08-04)
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic

Artigos

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

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