59773
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
analytical standard
Sinônimo(s):
NNAL
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10 MG
R$ 4.368,00
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10 MG
R$ 4.368,00
About This Item
Fórmula empírica (Notação de Hill):
C10H15N3O2
Número CAS:
Peso molecular:
209.25
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24
Produtos recomendados
grau
analytical standard
Nível de qualidade
Ensaio
≥92.0% (TLC)
prazo de validade
limited shelf life, expiry date on the label
técnica(s)
HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable
aplicação(ões)
cleaning products
cosmetics
food and beverages
personal care
Formato
neat
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
CN(N=O)CCCC(O)C1=CN=CC=C1
InChI
1S/C10H15N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8,10,14H,3,5,7H2,1H3
chave InChI
OGRXKBUCZFFSTL-UHFFFAOYSA-N
Categorias relacionadas
Descrição geral
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol is one of the major metabolite of nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, which is a carcinogen responsible in inducing lung cancer in smokers.[1]
Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706031
Aplicação
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Sung Hoon Jeong et al.
Scientific reports, 11(1), 4536-4536 (2021-02-27)
Children are at risk of exposure to secondhand smoke. We aimed to evaluate the extent of their exposure to it in relation to their parents' smoking status by using biomarkers relevant to smoking. We evaluated 847 school-age children (6-12 years) who
Steven G Carmella et al.
Chemical research in toxicology, 15(4), 545-550 (2002-04-16)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific lung carcinogen which may play an important role as a cause of lung cancer in smokers. NNK is extensively metabolized to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), which like NNK is a potent pulmonary carcinogen. NNAL in turn is
M E Staretz et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(2), 154-162 (1997-02-01)
We compared the metabolism in human hepatic microsomes of three tobacco smoke carcinogens believed to be involved in the induction of cancer in humans: benzo[a]pyrene (BaP),4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and N'-nitrosonomicotine (NNN). The metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a major metabolite of NNK
M E Staretz et al.
Carcinogenesis, 18(9), 1715-1722 (1997-11-05)
Phenethyl isothiocyanate (PEITC), a cruciferous vegetable component, inhibits lung tumor induction by the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). To gain insight into the mechanism of PEITC lung tumor inhibition, we examined, in male F344 rats, the effects of dietary PEITC
Yi Wang et al.
Cancer prevention research (Philadelphia, Pa.), 13(5), 483-492 (2020-02-28)
Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung cancer chemoprevention with smoking cessation is one
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