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30873

Supelco

Rhein

analytical standard

Sinônimo(s):

4,5-Dihydroxyanthraquinone-2-carboxylic acid, 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, Cassic acid, Chrysazin 3-carboxylic acid, Monorhein, Rheic acid, Rhubarb yellow

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About This Item

Fórmula empírica (Notação de Hill):
C15H8O6
Número CAS:
Peso molecular:
284.22
Beilstein:
2222155
Número CE:
Número MDL:
Código UNSPSC:
85151701
ID de substância PubChem:
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

Ensaio

≥95.0% (HPLC)

prazo de validade

limited shelf life, expiry date on the label

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

Impurezas

≤5.0% water

pf

≥300 °C (lit.)

aplicação(ões)

food and beverages

formato

neat

cadeia de caracteres SMILES

OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI

1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

chave InChI

FCDLCPWAQCPTKC-UHFFFAOYSA-N

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Descrição geral

Rhein is an active component of rhubarb (Rheum officinale), a medicinal herb in traditional Chinese medicine (TCM). It is known to exhibit antibacterial and anti-inflammatory activities.

Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Rhein may be used as an analytical reference standard for the determination of the analyte in rat plasma and rhubarb roots, dock flowers and senna leaves by column-switching high-performance liquid chromatography and normal-phase high performance liquid chromatography, respectively.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2


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Certificados de análise (COA)

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Supelco

68909

Sennoside A

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Sigma-Aldrich

E7881

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Rhein protects against acetaminophen-induced hepatic and renal toxicity.
Zhao YL, et al.
Food And Chemical Toxicology, 49(8), 1705-1710 (2011)
Simultaneous determination of baicalin, rhein and berberine in rat plasma by column-switching high-performance liquid chromatography.
Yi L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 838(1), 50-55 (2006)
Determination of anthraquinones in rhubarb roots, dock flowers and senna leaves by normal-phase high performance liquid chromatography.
Djozan DJ and Assadi Y
Talanta, 42(6), 861-865 (1995)
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Zhang Q, et al.
Kidney International, 91(1), 144-156 (2017)
Baoen Chen et al.
Journal of the American Chemical Society, 134(43), 17963-17971 (2012-10-11)
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N(6)-methyladenosine (m(6)A) residues in mRNA in vitro and inside cells. FTO is the first RNA demethylase discovered that also serves a major regulatory function in mammals. Together with

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