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Merck
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Documentos

03334

Supelco

Dansylhydrazine

for LC-MS derivatization, LiChropur™, ≥95% (HPLC)

Sinônimo(s):

5-(Dimethylamino)-1-naphthalenesulfonic hydrazide, 5-(Dimethylamino)naphthalene-1-sulfono­hydra­zide, Dns-Hz

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About This Item

Fórmula linear:
(CH3)2NC10H6SO2NHNH2
Número CAS:
33008-06-9
Peso molecular:
265.33
Beilstein:
2868662
Número CE:
251-337-7
Número MDL:
MFCD00003986
Código UNSPSC:
41116105
ID de substância PubChem:
329747590
NACRES:
NA.22

Nível de qualidade

100

Ensaio

≥95% (HPLC)

qualidade

LiChropur™

técnica(s)

LC/MS: suitable

pf

126-130 °C (lit.)

adequação

conforms to structure for Infrared spectrum

cadeia de caracteres SMILES

CN(C)c1cccc2c(cccc12)S(=O)(=O)NN

InChI

1S/C12H15N3O2S/c1-15(2)11-7-3-6-10-9(11)5-4-8-12(10)18(16,17)14-13/h3-8,14H,13H2,1-2H3

chave InChI

KPQYDVAFRDWIBW-UHFFFAOYSA-N

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Descrição geral

Dansylhydrazine (DNSH) is a fluorescent reagent which is commonly utilized for derivatization of carbonyl compounds.

Aplicação

Suitable for LC-MS derivatization.
DNSH has been used for the analytical derivatization of malondialdehyde prior to its determination in human plasma by liquid chromatography-mass spectrometry (LC-MS).
It may be used as a derivatization agent for thujone prior to its determination in white Italian vermouth samples by reversed phase LC with fluorescence detection combined with tandem MS and as a fluorescent label for the quantification of neuroactive steroids, alphaxalone and pregnanolone in plasma by isocratic reversed-phase high-performance liquid chromatography (RP-HPLC).

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Informações legais

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Declarações de precaução

P261 - P305 + P351 + P338

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
BCCB8488
BCBR7159V
BCBP5880V
BCBN7611V
BCBN7611

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Determination of malondialdehyde in human plasma by fully automated solid phase analytical derivatization.
Lord, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877(13), 1292-1298 (2009)
High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats.
Visser, et al.
Journal of Chromatography. B, Biomedical Applications, 745(2), 357-363 (2000)
Determination of thujone by derivatization with dansylhydrazine and liquid chromatography.
Scott, et al.
Journal of Liquid Chromatography and Related Technologies, 27(6), 1071-1081 (2004)
Tomofumi Santa
Biomedical chromatography : BMC, 25(1-2), 1-10 (2010-11-09)
Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and
S A Visser et al.
Journal of chromatography. B, Biomedical sciences and applications, 745(2), 357-363 (2000-10-24)
This report describes a rapid and sensitive analytical method for the quantification of the neuroactive steroids alphaxalone and pregnanolone in rat plasma using derivatization with dansyl hydrazine as fluorescent label. The method involves protein precipitation, alkaline derivatization and extraction of

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