MABC203

Anti-Yes-associated protein (YAP1) Antibody, clone 4D11.1

clone 4D11.1, from mouse

• Sinônimo(s): Yorkie homolog, Yes-associated protein, Yap65
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 4D11.1, monoclonal
• reatividade de espécies: human
• técnica(s): immunocytochemistry: suitable; western blot: suitable
• Isotipo: IgG1κ
• nº de adesão NCBI: NP_001123617
• nº de adesão UniProt: P46937
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... YAP1(10413)

Descrição

Descrição geral

The YAP1 gene encodes a protein that binds to the SH3 (Src homology 3) domain of the Yes proto-oncogene product. As a transcriptional regulator, it can act as a coactivator and a corepressor, and serves as a critical downstream regulatory target in the Hippo signaling pathway. Additionally, it plays a critical role in regulating organ size and in tumor suppression by restricting proliferation and promoting apoptosis. The human YAP1 gene is well conserved among higher eukaryotes, but may not be conseved in yeast. Yes-associated protein expression is almost ubiquitous in adult human tissues, but is not detectable in peripheral blood leukocytes.

Imunogênio

GST-tagged recombinant protein corresponding to human Yes-associated protein (YAP1).

Aplicação

Anti-Yes-associated protein (YAP1) Antibody, clone 4D11.1 detects level of Yes-associated protein (YAP1) & has been published & validated for use in WB & IC.

Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Yes-associated protein (YAP1) in HeLa and A431 cells.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Qualidade

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Yes-associated protein (YAP1) in 10 µg of HeLa cell lysate.

Descrição-alvo

~65 kDa observed

forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ supernatant containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
Hela cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable