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Documentos Principais

EZHPI

Millipore

Human Proinsulin ELISA Kit

measures and quantifies Proinsulin levels in 20 μL serum or plasma

Sinônimo(s):

Human Proinsulin Detection, Proinsulin ELISA

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About This Item

Código UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.32
Preço e disponibilidade não estão disponíveis no momento.

Nome do produto

Human Total Proinsulin ELISA, This Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.

Nível de qualidade

200

reatividade de espécies

human

embalagem

kit of 1 × 96 wells

Parâmetros

20 μL sample volume (4hr assay)

assay range

accuracy: 88-103%
linearity: 84-120%
sensitivity: 0.5 pM
standard curve range: 2-200 pM

técnica(s)

ELISA: suitable

entrada

sample type serum
sample type plasma (K2 EDTA)

nº de adesão NCBI

NM_000207.2

nº de adesão UniProt

P01308

aplicação(ões)

research use

método de detecção

colorimetric (450nm)

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

Categorias relacionadas

Descrição geral

Proinsulin, the precursor of insulin and C-peptide, is made by the β cells of the pancreas. Proinsulin formed by the cleavage of pre-proinsulin contains B- and A-domains linked through the connecting domain. Proinsulin interacts with insulin receptor-A (IR-A) isoform present in the nervous system and exhibits antiapoptotic and neuroprotective effects in the developing and postnatal nervous system. Elevated levels of proinsulin serve as a marker for secretory β-cell dysfunction. Increased levels of this hormone are also observed in patients with type 2 diabetes and impaired glucose tolerance. This kit measures the intact and intermediate metabolic forms of human proinsulin.

Aplicação

Human Total Proinsulin ELISA has been used to measure plasma, serum, eye, and retinal levels of human proinsulin.

Outras notas

Research Sub Category
Obesity
Metabolic Disorders
Research Category
Metabolism
20 μL sample volume 3 hour assay, room temperature

Exoneração de responsabilidade

For research use only. Not for use in diagnostic procedures.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Warning

Frases de perigo

H290,H317

Classificações de perigo

Met. Corr. 1 - Skin Sens. 1

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Andreas Pfützner et al.
Journal of diabetes science and technology, 5(3), 784-793 (2011-07-05)
Insulin resistance (IR) and deterioration of beta-cell secretion are main features in the development of type 2 diabetes, which is reflected in increasing serum intact proinsulin levels in later disease stage. Introduction of stable assays that are able to distinguish
Michael A Weiss
The Journal of biological chemistry, 284(29), 19159-19163 (2009-04-28)
Insulin plays a central role in the regulation of vertebrate metabolism. The hormone, the post-translational product of a single-chain precursor, is a globular protein containing two chains, A (21 residues) and B (30 residues). Recent advances in human genetics have
Carolina Isiegas et al.
Investigative ophthalmology & visual science, 57(8), 3610-3618 (2016-07-09)
The induction of proinsulin expression by transgenesis or intramuscular gene therapy has been shown previously to retard retinal degeneration in mouse and rat models of retinitis pigmentosa (RP), a group of inherited conditions that result in visual impairment. We investigated
Flora de Pablo et al.
Frontiers in molecular neuroscience, 11, 426-426 (2018-12-12)
Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied
Alonso Sánchez-Cruz et al.
Cell death & disease, 13(4), 383-383 (2022-04-22)
Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor dysfunction and death. The insulin receptor

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