ABT179

Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody)

from rabbit, purified by affinity chromatography

• Sinônimo(s): Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, Neuregulin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, HRG, Neu differentiation factor, Sensory and motor neuron-der
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: human
• reatividade da espécie (prevista por homologia): chimpanzee (based on 100% sequence homology)
• técnica(s): immunohistochemistry: suitable; western blot: suitable
• nº de adesão NCBI: NP_001153467
• nº de adesão UniProt: Q02297
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... NRG1(3084)

Descrição

Descrição geral

Neuregulin isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9). Neuregulin Type I/II serve as direct ligands for ERBB3 and ERBB4 tyrosine kinase receptors that regulate development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Type I isoforms are the predominant forms expressed in the endocardium. Type II is the major form in skeletal muscle cells, and is expressed in the spinal cord, brain, adult heart, placenta, lung, liver, kidney, and pancreas. Neuregulin-HBD refers to the heparin binding domain of Type I/II Neuregulin.

Especificidade

This antibody is expected to cross-react to all Alpha and Beta isoforms (Alpha1A, Alpha2B, Alpha3; and Beta1/1A, Beta2, Beta3), also known as Type I.

Imunogênio

Epitope: Extracellular domain

GST-tagged recombinant protein corresponding to the extracellular domain of human Pro-neuregulin-1, membrane-bound isoform (NRG1).

Aplicação

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pro-neuregulin-1, membrane-bound isoform (NRG1) in human cardiac myocytes and human cerebellum tissue.

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

This Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody) is validated for use in Western Blotting and Immunohistochemistry for the detection of Pro-neuregulin-1, membrane-bound isoform (NRG1).

Qualidade

Evaluated by Western Blotting in PC3 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pro-neuregulin-1, membrane-bound isoform (NRG1) in 10 µg of PC3 cell lysate.

Descrição-alvo

~110 and ~58 kDa observed. May detect multiple isoforms (Alpha1A, Alpha2B, Alpha3; and Beta1/1A, Beta2, Beta3).

forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable