ABN1362
Anti-RBPMS Antibody
from rabbit, purified by affinity chromatography
Sinônimo(s):
RNA-binding protein with multiple splicing, RBPMS, RBP-MS, Heart and RRM expressed sequence, Hermes
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.43
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
purificado por
affinity chromatography
reatividade de espécies
human, mouse, rat
técnica(s)
immunofluorescence: suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... RBPMS(11030)
Descrição geral
RNA-binding protein with multiple splicing (UniProt Q93062; also known as Heart and RRM expressed sequence, Hermes, RBP-MS) is encoded by the RBPMS (also known as HERMES) gene (Gene ID 11030) in human. RBPMS is a member of the RRM (RNA recognition motif) family of RNA-binding proteins. Transcriptome-wide study using photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in HEK293 cells reveals both exonic mature and intronic pre-mRNA-binding sites, in agreement with the nuclear and cytoplasmic localization of the RRM family proteins. RBPMS is found to be exclusively expressed in retinal ganglion cells (RGCs) and displaced RGCs (dRGCs). RBPMS expression can therefore be utitized as a RGC marker, and the RBPMS gene promoter could be utilized for driving RGC-specific transgene expression.
Especificidade
Expected to react with all five spliced isoforms (UniProt Q93062-1 through Q93062-5).
Imunogênio
Epitope: N-terminal region.
KLH-conjugated linear peptide corresponding to a sequence from the N-terminal region of human RBPMS.
Aplicação
Anti-RBPMS Antibody is an antibody against RBPMS for use in Western Blotting, Immunofluorescence.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Sensory & PNS
Sensory & PNS
Western Blotting Analysis: A representative lot detected endogenous RBPMS in mouse and rat retina extracts, as well as exogenously expressed human RBPMS in transfected HEK293T cells (Rodriguez, A.R., et al. (2014). J. Comp. Neurol. 522(6):1411-1443).
Immunofluorescence Analysis: A representative lot detected RBPMS immunoreactivity primarily associated with cell bodies located in the ganglion cell layer (GCL) of paraformaldehyde-fixed mouse retinas by fluorescent immunohistochemistry using whole-mounted retinas (Rodriguez, A.R., et al. (2014). J. Comp. Neurol. 522(6):1411-1443).
Immunofluorescence Analysis: An 1:5,000 dilution of a representative lot detected RBPMS immunoreactivity among cells in the ganglion cell layer (GCL) of paraformaldehyde-fixed mouse retinas by fluorescent immunohistochemistry (Courtesy of Dr. Nicholas Brecha, David Geffen School of Medicine at UCLA).
Immunofluorescence Analysis: A representative lot detected RBPMS immunoreactivity primarily associated with cell bodies located in the ganglion cell layer (GCL) of paraformaldehyde-fixed mouse retinas by fluorescent immunohistochemistry using whole-mounted retinas (Rodriguez, A.R., et al. (2014). J. Comp. Neurol. 522(6):1411-1443).
Immunofluorescence Analysis: An 1:5,000 dilution of a representative lot detected RBPMS immunoreactivity among cells in the ganglion cell layer (GCL) of paraformaldehyde-fixed mouse retinas by fluorescent immunohistochemistry (Courtesy of Dr. Nicholas Brecha, David Geffen School of Medicine at UCLA).
Qualidade
Evaluated by Western Blotting in mouse embryonic stem cell (mESC) lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected RBPMS in 10 µg of mouse embryonic stem cell (mESC) lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected RBPMS in 10 µg of mouse embryonic stem cell (mESC) lysate.
Descrição-alvo
~25 kDa observed
forma física
Affinity purified
Purified rabbit polyclonal antibody in PBS with 1% BSA and 0.09 % sodium azide.
Armazenamento e estabilidade
Stable for 1 year at 2-8°C from date of receipt.
Outras notas
Concentration: Please refer to lot specific datasheet.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Descrição
Preços
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Alexandra Bernardo-Colón et al.
Frontiers in neuroscience, 13, 719-719 (2019-07-30)
Indirect traumatic optic neuropathy (ITON) is a condition that is often associated with traumatic brain injury and can result in significant vision loss due to degeneration of retinal ganglion cell (RGC) axons at the time of injury or within the
Chelsea Guymer et al.
Translational vision science & technology, 9(6), 28-28 (2020-08-22)
The ability to accurately quantify immunohistochemically labeled retinal ganglion cells (RGCs) on wholemounts is an important histopathological determinant in experimental retinal research. Traditionally, this has been performed by manual or semi-automated counting of RGCs. Here, we describe an automated software
Chelsea Guymer et al.
Translational vision science & technology, 9(6), 28-28 (2020-08-22)
The ability to accurately quantify immunohistochemically labeled retinal ganglion cells (RGCs) on wholemounts is an important histopathological determinant in experimental retinal research. Traditionally, this has been performed by manual or semi-automated counting of RGCs. Here, we describe an automated software
Lucia G Le Roux et al.
Cells, 9(5) (2020-05-28)
We illuminate a possible explanatory pathophysiologic mechanism for retinal cellular neuropathy by means of a novel diagnostic method using ophthalmoscopic imaging and a molecular imaging agent targeted to fast axonal transport. The retinal neuropathies are a group of diseases with
Ye Xie et al.
Cell reports, 39(11), 110960-110960 (2022-06-16)
Reprogramming glial cells to convert them into neurons represents a potential therapeutic strategy that could repair damaged neural circuits and restore function. Recent studies show that downregulation of the RNA-binding protein PTBP1 leads to one-step conversion of Müller glia (MG)
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