8.51200

DOTA-tris(tert-butyl ester)

Novabiochem^®

• Sinônimo(s): DOTA-tris(tert-butyl ester), Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
• Fórmula empírica (Notação de Hill): C₂₈H₅₂N₄O₈
• Número CAS: 137076-54-1
• Peso molecular: 572.73
• Número MDL: MFCD02259697
• Código UNSPSC: 12352108

Propriedades

• Nível de qualidade: 200
• linha de produto: Novabiochem^®
• Formulário: powder
• adequação da reação: reagent type: fluorescent-labelling reagent
• fabricante/nome comercial: Novabiochem^®
• pf: 88-93 °C
• aplicação(ões): peptide synthesis
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34)
• chave InChI: RVUXZXMKYMSWOM-UHFFFAOYSA-N

Descrição

Descrição geral

The most convenient reagent for the labeling of a peptide with DOTA ^[1]. This reagent has good solubility in DMF and DCM, and its free carboxyl group can be easily activated using uronium or phosphonium coupling reagents, enabling it to be attached to peptide amino groups. Removal of the t-butyl ester groups from the DOTA occurs during the course of the TFA-mediated cleavage reaction. The progress of the reaction should be monitored as the cleavage of these esters is slow, owing to the proximity of the basic ring nitrogens.

Literature references

^[1] L. M. De León-Rodrýguez & Z. Kovacs (2008) Bioconjugate Chem, 19, 391.

Nota de análise

Colour (visual): white to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (NMR): ≥ 95.0 %
Identity (NMR): passes test
NMR-spectrum: passes test

Informações legais

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°C): Not applicable