654255

TNF-α Antagonist

≥95% (HPLC), lyophilized, TNF-α antagonist, Calbiochem^®

• Sinônimo(s): TNF-α Antagonist, TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
• Fórmula empírica (Notação de Hill): C₅₈H₇₁N₁₁O₁₅S₂
• Peso molecular: 1226.38
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• product name: TNF-α Antagonist, The TNF-α Antagonist controls the biological activity of TNF-α.
• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: lyophilized
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• solubilidade: water: 1 mg/mL; 5% acetic acid: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.

Ações bioquímicas/fisiológicas

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 5 µM as TNF-α antagonist

Advertência

Toxicity: Standard Handling (A)

Sequência

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)

Outras notas

Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

Informações legais

Sold under license of U.S. Patent 6,265,535.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable