553018-M

RAF Kinase Inhibitor VII

• Sinônimo(s): RAF Kinase Inhibitor VII, 1-(4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
• Fórmula empírica (Notação de Hill): C₂₁H₁₅ClF₃N₅O₃S
• Número CAS: 884339-61-1
• Peso molecular: 509.89
• Código UNSPSC: 12352200

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• forma: powder
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: caramel
• solubilidade: DMSO: 50 mg/mL
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-Raf^V600E activity (IC₅₀ = 1 nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out conformation. Reported to effectively inhibit Raf^V600E-dependent ERK phosphorylation (IC₅₀ = 610 nM) and growth of human melanoma WM266.4 cells (GI₅₀ = 470 nM).

Advertência

Toxicity: Regulatory Review (Z)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Menard, D., et al. 2009. J. Med. Chem.52, 3881.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable