475874-M

MK571, Sodium Salt

A selective, competitive antagonist of leukotriene D4 (LTD4) (K_i = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).

• Sinônimo(s): MK571, Sodium Salt, L 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt
• Fórmula empírica (Notação de Hill): C₂₆H₂₆ClN₂O₃S₂ · Na
• Número CAS: 115104-28-4
• Peso molecular: 537.07
• Código UNSPSC: 12352211

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥90% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated
• cor: off-white
• solubilidade: DMSO: 10 mg/mL; water: 200 mg/mL
• temperatura de armazenamento: −20°C
• InChI: 1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+
• chave InChI: AXUZQJFHDNNPFG-UXBLZVDNSA-N

Descrição

Descrição geral

A selective, competitive antagonist of leukotriene D₄ (LTD₄) (K_i = 2.1 nM for inhibition of [³H]LTD₄ binding to human lung membranes). Also inhibits multidrug resistance-associated protein 1 (MRP1).

A selective, competitive antagonist of leukotriene D₄ (LTD₄) receptor (K_i = 2.1 nM for inhibition of [³H]LTD₄ binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).

Ações bioquímicas/fisiológicas

Primary Target
Antagonist of leukotriene D4 (LTD4)

Target K_i: 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.

Outras notas

Olson, D.P., et al. 2001. Cytometry46, 105.
Van der Kolk, D.M., et al. 1998. Clin. Cancer Res.4, 1727.
Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol.67, 17.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable