434625

Leukotriene B₄

≥97% (HPLC), oil, proinflammatory agent, Calbiochem^®

• Sinônimo(s): Leukotriene B₄, LTB₄, 5(S),12(R)-Dihydroxy-6- cis-8- trans-10- trans-14- cis-eicosatetraenoic Acid
• Fórmula empírica (Notação de Hill): C₂₀H₃₂O₄
• Número CAS: 71160-24-2
• Peso molecular: 336.47
• Número MDL: MFCD00135630
• Código UNSPSC: 12352211
• NACRES: NA.77

Propriedades

• Nome do produto: Leukotriene B₄, Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium.
• descrição: Merck USA index - 14, 5455
• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• Formulário: oil
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: clear
• solubilidade: ethanol: soluble
• Condições de expedição: wet ice
• temperatura de armazenamento: −70°C
• cadeia de caracteres SMILES: OC(CCCC(=O)O)\C=C\C=C\C=C\C(O)C\C=C\CCCCC
• InChI: 1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6+,14-10+,15-11+
• chave InChI: VNYSSYRCGWBHLG-XUOUMLBJSA-N

Descrição

Descrição geral

Potent inflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema.

Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema and asthma.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Polymorphonuclear leukocytes

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Flammable (J)

forma física

In Ethanol.

Reconstituição

Following initial thaw, aliquot and freeze (-70°C).

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kendall, A.P., et al. 1995. Anesthesia 50, 590.
Dokter, W.H., et al. 1994. Leukemia 8, 1181.
Jedlitschky, G., et al. 1991. J. Biol. Chem.266, 24763.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS02,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H319
• Declarações de precaução: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Flam. Liq. 2
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 2