230752

Chromomycin A₃

Antitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 to distinguish chromosomes by their total DNA content and DNA base composition.

• Sinônimo(s): Chromomycin A₃, Toyomycin
• Fórmula empírica (Notação de Hill): C₅₇H₈₂O₂₆
• Número CAS: 7059-24-7
• Peso molecular: 1183.25
• Número MDL: MFCD00043151
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥90% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: ethanol: 10 mg/mL
• fluorescência: λ_ex ~445 nm; λ_em ~575 nm
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3/t22-,23-,24-,25-,26-,27+,32+,33-,35-,36-,37-,38-,39+,40+,41+,42+,46+,47-,48-,52+,53+,54+,55+,56+,57+/m1/s1
• chave InChI: ZYVSOIYQKUDENJ-WKSBCEQHSA-N

Descrição

Descrição geral

Antibiotic that inhibits RNA synthesis by way of DNA-dependent RNA polymerase. Fluorescent dye that can be used in conjunction with Bisbenzimide H33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA concentration and their DNA base composition. Binds to G:C pairs of helical DNA (Mg²⁺ required) but does not intercalate the A:T pairs, which preferentially bind Bisbenzimide H33258.

Antitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA content and DNA base composition. Reversibly interacts with DNA in the presence of Mg²⁺. Binds to G:C pairs of helical DNA but does not intercalate.

Advertência

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Reconstituição

Following recosntitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Aich, P., et al. 1992. Biochemistry31, 2988.
Saccone, S., et al. 1992. Proc. Natl. Acad. Sci. USA89, 4913.
Van Dilla, M.A., et al. 1983. Science220, 620.
Mizuno, K. 1963. J. Antibiot.16, 22.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 1 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable