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Documentos

07-687

Sigma-Aldrich

Anti-Cyclin E Antibody

Upstate®, from rabbit

Sinônimo(s):

Anti-CCNE, Anti-pCCNE1

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

affinity purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

rat, mouse

fabricante/nome comercial

Upstate®

técnica(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CCNE1(898)

Descrição geral

Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Especificidade

Cyclin E

Imunogênio

KLH-conjugated, synthetic peptide corresponding to amino acids 378-396 (GVLTPPHSSKKQSSEQETE) of rat Cyclin E

Aplicação

Detect Cyclin E with Anti-Cyclin E Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB & IHC.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

Qualidade

routinely evaluated by immunoblot on RIPA lysates from 3T3/A31 cells

Descrição-alvo

Mr 52kDa

Ligação

Replaces: 04-223

forma física

ImmunoAffinity Purified
PBS containing 0.1% sodium azide and 0.2% gelatin.

Armazenamento e estabilidade

stable for 1 year at 4°C from date of shipment

Nota de análise

Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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The role of cyclin E in the regulation of entry into S phase.
Sauer, K and Lehner, C F
Progress in Cell Cycle Research, 1, 125-139 (1995)
Xiaoyun Tang et al.
Theranostics, 12(13), 5675-5690 (2022-08-16)
LPP2 is one of three enzymes in the lipid phosphate phosphatase family (LPP1-3) that dephosphorylate extracellular and intracellular bioactive lipid phosphates and pyrophosphates. LPP2 increases cell growth and LPP2 expression is elevated in a variety of malignancies, implying that LPP2
Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2.
Prall, O W, et al.
The Journal of Biological Chemistry, 272, 10882-10894 (1997)
Cell cycle regulation in mouse heart during embryonic and postnatal stages.
Aiko Ikenishi,Hitomi Okayama,Noriko Iwamoto,Satoshi Yoshitome,Shoji Tane,Kazuomi Nakamura et al.
Development, Growth & Differentiation null
Cyclin A: function and expression during cell proliferation.
Desdouets, C, et al.
Progress in Cell Cycle Research, 1, 115-123 (1995)

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