23-027-M

b-catenin Protein, activated, 10 µg

Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a (Item # 14-492). For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

• Sinônimo(s): Catenin beta-1
• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

Propriedades

• fonte biológica: human
• Nível de qualidade: 100; 300
• recombinante: expressed in Sf21 cells
• fabricante/nome comercial: Upstate^®
• técnica(s): activity assay: suitable
• nº de adesão NCBI: NM_001904

Descrição

Descrição geral

β-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.

N-terminal GST-tagged, recombinant human Smurf1 full length, expressed in E coli.

Aplicação

Ubiquitination Cascade Comoponent: Substrate

forma física

Purified using immobilized metal affinity chromatography.

Outras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): nwg