219261

Catalase, Aspergillus niger

Catalase, Aspergillus niger, CAS 9001-05-2, is a native, long-acting, extremely stable form of catalase that is active over a wide pH range (pH 1 - 12).

• Sinônimo(s): Catalase, Aspergillus niger
• Número CAS: 9001-05-2
• Número da licença da enzima: 1.11.1.6 (BRENDA, IUBMB)
• Número MDL: MFCD00081483
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• forma: lyophilized powder
• atividade específica: ≥10,000 units/mg protein; ≥4000 units/mg dry wt.
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: green
• solubilidade: H₂O: 1 mg/mL
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• InChI: 1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
• chave InChI: NUVBSKCKDOMJSU-UHFFFAOYSA-N

Descrição

Descrição geral

Research area: Cell Signaling

Catalase, Aspergillus niger, is a native, long-acting, extremely stable form of catalase that is active over a wide pH range (pH 1 - 12). Composed of four protein subunits, each containing a heme group bound to its active site, it is one of the most important antioxidant enzymes present in almost all aerobic organisms.

Aplicação

Catalase may be used in:

• Industrial applications for eliminating hydrogen peroxide, which is utilized as an oxidizing, bleaching, or sterilizing agent.
• Food industry and egg processing, often in conjunction with other enzymes.
• Food preservation methods in combination with glucose oxidase, where superoxide dismutase produces H2O2, which is subsequently eliminated by catalase.
• Preservation process, along with glucose oxidase.

Ações bioquímicas/fisiológicas

Catalase is responsible for breaking down two hydrogen peroxide molecules into one oxygen molecule and two water molecules in a two-step reaction. It plays a crucial role in regulating the cellular level and catabolism of hydrogen peroxide which in turn shields the cells from oxidative damage. Its malfunctioning and deficiency is linked to various diseases, including vitiligo, diabetes mellitus, anemia, cardiovascular diseases, bipolar disorders, Wilson disease, certain dermatological disorders, Alzheimer′s disease, hypertension, and schizophrenia. Anomalies in catalase activity are related to acatalasemia or Takahara disease, a rare genetic disorder.

Advertência

Toxicity: Standard Handling (A)

Definição da unidade

One unit is defined as the amount of enzyme that will decompose 1.0 µmol H₂O₂ per min at 30°C, pH 7.0.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Note: 1 KU = 1000 units

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H334
• Declarações de precaução: P261 - P284 - P501
• Classificações de perigo: Resp. Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable