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Documentos Principais

LM2001

Avanti

Sphinganine (d17:0)

heptadecasphinganine, ethanol solution

Sinônimo(s):

(2S,3R)-2-aminoheptadecane-1,3-diol, C17 Sphinganine

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About This Item

Fórmula empírica (Notação de Hill):
C17H37NO2
Número CAS:
Peso molecular:
287.48
Código UNSPSC:
12352211
NACRES:
NA.25

Formulário

ethanol solution

embalagem

pkg of 1 × 1 mL (LM2001-1EA)

fabricante/nome comercial

Avanti Research - A Croda Brand LM2001

concentração

~10 μg/mL (Refer to C of A for lot specific concentration.)

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCC

InChI

1S/C17H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(20)16(18)15-19/h16-17,19-20H,2-15,18H2,1H3/t16-,17+/m0/s1

chave InChI

KFQUQCFJDMSIJF-DLBZAZTESA-N

Descrição geral

Sphinganine, also known as dihydrosphingosine is a sphingoid base precursor of ceramide.

Aplicação

Sphinganine (d17:0) has been used as a constituent of the internal standard mixture in mass spectrometry.

Ações bioquímicas/fisiológicas

Sphinganine (SPA) is involved in sphingolipid biosynthesis pathway. It is free from the double bond. SPA has an ability to inhibit the activity of protein kinase c. SPA accumulation enables fumonisin B1 to stimulate apoptosis.
Sphinganine plays a vital role in cell regulation, cell growth modulation and signal transmission, functioning as an inhibitor of protein kinase C. It inhibits the low-density lipoprotein-induced esterification of cholesterol by the blockage of post-lysosomal cholesterol transport. Sphinganine is useful as a biomarker for studying microbial diversity.

Embalagem

2 mL Amber Glass Sealed Ampule (LM2001-1EA)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

FlameExclamation mark

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Eye Irrit. 2 - Flam. Liq. 2

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

55.4 °F - closed cup

Ponto de fulgor (°C)

13.0 °C - closed cup


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Urinary metabolomic profiling in Zucker diabetic fatty rats with type 2 diabetes mellitus treated with glimepiride, metformin, and their combination
Dong Y, et al.
Molecules (Basel), 21(11), 1446-1446 (2016)
A stereoselective synthesis of dihydrosphingosine
Fernandes RA and Kumar P
European Journal of Organic Chemistry, 2000(20), 3447-3449 (2000)
Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase
Enongene EN, et al.
Toxicological Sciences, 67(2), 173-181 (2002)
Quantification of sphingosine and sphinganine from crude lipid extracts by HPLC electrospray ionization tandem mass spectrometry
Lieser B, et al.
Journal of Lipid Research, 44(11), 2209-2216 (2003)
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2
Takabe, et al.
Test, 285(14) (2010)

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