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Documentos Principais

900125E

Avanti

17(S)-HDHA

Avanti Research - A Croda Brand 900125E, ethanol solution

Sinônimo(s):

17(S)-hydroxy Docosahexaenoic acid

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100 μG
R$ 1.160,00
500 μG
R$ 2.999,00

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100 μG
R$ 1.160,00
500 μG
R$ 2.999,00

About This Item

Fórmula empírica (Notação de Hill):
C22H32O3
Número CAS:
Peso molecular:
344.49
Número MDL:
Código UNSPSC:
12352211
NACRES:
NA.25

R$ 1.160,00


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Formulário

ethanol solution

embalagem

pkg of 1 × 1 mL (900125E-100ug)
pkg of 1 × 1 mL (900125E-500ug)

fabricante/nome comercial

Avanti Research - A Croda Brand 900125E

concentração

0.1 mg/mL (900125E-100ug)
0.5 mg/mL (900125E-500ug)

tipo de lipídio

neutral lipids
neutral glycerides

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

cadeia de caracteres SMILES

CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O

InChI

1S/C22H32O3/c1-2-3-15-18-21(23)19-16-13-11-9-7-5-4-6-8-10-12-14-17-20-22(24)25/h3,5-8,11-16,19,21,23H,2,4,9-10,17-18,20H2,1H3,(H,24,25)/b7-5-,8-6-,13-11-,14-12-,15-3-,19-16+/t21-/m0/s1

chave InChI

SWTYBBUBEPPYCX-YTQNUIGOSA-N

Descrição geral

Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (PUFA) with 22 carbons and six double bonds. The first double bond occurring at position three from the methyl terminus (22:6 n-3).[1] DHA is a component of phospholipid membranes and the myelin sheath. It is the most abundant PUFA found in the brain and localized predominantly to the gray matter.[2]

Ações bioquímicas/fisiológicas

Docosahexaenoic acid (DHA) exhibits various physiological processes such as regulating signal transduction pathways, neurotransmission, production of neurons and formation of myelin sheath around the axon. It is also associated with the membrane receptor function and synaptic plasticity. DHA supports membrane integrity, fluidity and organization. It is also found to be involved in neuroinflammation. DHA plays a vital role in the development and maturation of the brain.[2] 17(S)-HDHA (hydroxy docosahexaenoic acid) can serve as a precursor for specialized pro-resolving mediators (D-series).[3]

Embalagem

2 mL Amber Glass Sealed Ampule (900125E-100ug)
2 mL Amber Glass Sealed Ampule (900125E-500ug)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

FlameExclamation mark

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Eye Irrit. 2 - Flam. Liq. 2

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

55.4 °F - closed cup

Ponto de fulgor (°C)

13.0 °C - closed cup


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Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition, 460-460 (2019)
Michael J Weiser et al.
Nutrients, 8(2), 99-99 (2016-02-24)
Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid (PUFA) found in the brain and can affect neurological function by modulating signal transduction pathways, neurotransmission, neurogenesis, myelination, membrane receptor function, synaptic plasticity, neuroinflammation, membrane integrity and membrane organization.
Miaomiao Ruan et al.
Journal of the neurological sciences, 396, 247-253 (2018-12-12)
Glioblastoma (GBM) is a typical malignant tumor, and there are no effective drugs capable of improving patient survival. Docosahexaenoic acid (DHA), a nutrient essential to animal health and neurodevelopment, exerts an anticancer effect in several types of cancer. However, the

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