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860657P

Avanti

sphingosine-d7

Avanti Research™ - A Croda Brand 860657P, powder

Sinônimo(s):

D-erythro-sphingosine-d7

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R$ 1.154,00
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R$ 4.984,00

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About This Item

Fórmula empírica (Notação de Hill):
C18H30D7NO2
Número CAS:
1246304-34-6
Peso molecular:
306.54
Número MDL:
MFCD31806645
Código UNSPSC:
12352211
NACRES:
NA.25

R$ 1.154,00

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Formulário

powder

embalagem

pkg of 1 × 1 mg (860657P-1mg)
pkg of 1 × 5 mg (860657P-5mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 860657P

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC[C@@](N)([H])[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

chave InChI

WWUZIQQURGPMPG-AVMMVCTPSA-N

Descrição geral

Sphingosine-d7 is a deuterated derivative of sphingosine. Sphingosine is an important bioactive sphingolipid metabolite.[1] It is a 18-carbon amino alcohol derived from sphingomyelin. Sphingosine contains an unsaturated hydrocarbon chain.[2]

Aplicação

Sphingosine-d7 has been used as an internal standard in liquid chromatography–tandem mass spectrometry for quantitative analysis of sphingolipids in biological samples.[3][4][5]

Ações bioquímicas/fisiológicas

Sphingosine negatively regulates cell proliferation and induces apoptosis.[1] It has an ability to regulate the activities of phospholipases, protein kinases, ion channels, cannabinoid receptor type 1 (CB-1) receptors and steroidogenic factor 1 (SF-1) receptors.[2] Sphingosine acts as a precursor for ceramide synthesis.[6]

Embalagem

5 mL Amber Glass Screw Cap Vial (860657P-1mg)
5 mL Amber Glass Screw Cap Vial (860657P-5mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Descrição
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Código de classe de armazenamento

11 - Combustible Solids

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the
Lipid Mediators and Their Metabolism in the Brain (2011)
Stephanie Schwalm et al.
The American journal of pathology, 187(11), 2413-2429 (2017-08-16)
Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring, and loss of kidney function. In this study, we investigated the role of sphingosine kinase-2 (SPHK2) on the progression of tubular fibrosis by
Iulia Zoicas et al.
Cells, 9(5) (2020-05-24)
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb)
Henning Carstens et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(6), 1015-1028 (2019-12-20)
Pulmonary infections with Pseudomonas aeruginosa (P. aeruginosa) or Staphylococcus aureus (S. aureus) are of utmost clinical relevance in patients with cystic fibrosis, chronic obstructive pulmonary disease, after trauma and burn, upon ventilation or in immuno-compromised patients. Many P. aeruginosa and
Irina Alecu et al.
Journal of lipid research, 58(1), 60-71 (2016-11-23)
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the inherited neuropathy, hereditary
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