810601C
Avanti
16:0-5 Doxyl PC
Avanti Research™ - A Croda Brand 810601C
Sinônimo(s):
1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine
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About This Item
Fórmula empírica (Notação de Hill):
C46H90N2O10P
Número CAS:
Peso molecular:
862.19
Número MDL:
Código UNSPSC:
51321705
NACRES:
NA.25
Preço e disponibilidade não estão disponíveis no momento.
Produtos recomendados
Ensaio
>99% (TLC)
Formulário
liquid
embalagem
pkg of 1 × 1 mL (810601C-1mg)
fabricante/nome comercial
Avanti Research™ - A Croda Brand 810601C
concentração
1 mg/mL (810601C-1mg)
tipo de lipídio
ESR probes
phospholipids
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
Descrição geral
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins[1] and as fluorescent quenchers in lipid bilayer structural studies.[2]
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes.[3] It is also an important component of the mucosal layer of the colon.[4] The 5th carbon of the sn-2 stearic acid chain of 1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine analog has a Doxyl PC, a spin probe[5] attached to it covalently.[6]
Aplicação
16:0-5 Doxyl PC may be used:
- as a component in virus-like large unilamellar vesicles (VL LUVs) to quench 4-chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD) fluorescence emission[7]
- in the preparation of multi-lamellar vesicles (MLVs) as a site-specific quencher to perform fluorescence quenching studies[8]
- in the preparation of spin-labelled multi-lamellar vesicles (MLVs)[9]
Ações bioquímicas/fisiológicas
Embalagem
5 mL Clear Glass Sealed Ampule (810601C-1mg)
Nota de preparo
To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies.[11] For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM.[2], Supplemental information
Informações legais
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Órgãos-alvo
Central nervous system, Liver,Kidney
Classe de risco de água (WGK)
WGK 3
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Certificados de análise (COA)
Lot/Batch Number
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The Membranes of Cells (2016)
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The Journal of biological chemistry, 292(13), 5571-5583 (2017-02-19)
The 4E10 antibody displays an extreme breadth of HIV-1 neutralization and therefore constitutes a suitable model system for structure-guided vaccine design and immunotherapeutics against AIDS. In this regard, the relevance of autoreactivity with membrane lipids for the biological function of
Integrative Medicine - E-Book (2017)
Jihong Bai et al.
Nature structural & molecular biology, 11(1), 36-44 (2004-01-14)
Synaptotagmin-1 (syt), the putative Ca2+ sensor for exocytosis, is anchored to the membrane of secretory organelles. Its cytoplasmic domain is composed of two Ca2+-sensing modules, C2A and C2B. Syt binds phosphatidylinositol 4,5-bisphosphate (PIP2), a plasma membrane lipid with an essential
Ali M Alaouie et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 182(2), 229-238 (2006-07-25)
An ultra-stable variable temperature accessory for EPR experiments with biological samples has been designed and tested. The accessory is comprised from a digitally controlled circulator bath that pumps fluid through high-efficiency aluminum radiators attached to an EPR resonator of a
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