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810314P

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NBD Phytosphingosine

Omega-NBD D-ribo-Phytosphingosine, powder

Sinônimo(s):

(2S,3S,4R)-2-amino-18-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)octadecane-1,3,4-triol

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About This Item

Fórmula empírica (Notação de Hill):
C24H41N5O6
Número CAS:
2260669-58-5
Peso molecular:
495.61
Código UNSPSC:
12352211
NACRES:
NA.25

Ensaio

>99% (TLC)

Formulário

powder

embalagem

pkg of 1 × 100 μg (810314P-100ug)
pkg of 1 × 250 μg (810314P-250ug)
pkg of 1 × 50 μg (810314P-50ug)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 810314P

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Descrição geral

Phytosphingosine (PHS) is one of the important constituent of phytoceramides. This sphingoid has a hydroxyl group at C-4 of the sphingoid long-chain base. PHS is a component of mammalian epidermis and is widely distributed in fungi and plants. Nitrobenzoxadiazole/7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) is a fluorescent conjugate.

Aplicação

NBD Phytosphingosine has been used as a substrate in ceramide synthase assays.

Ações bioquímicas/fisiológicas

Phytosphingosine (PHS) is capable of activating G-protein coupled receptor 120 (GPR120). Treating cultured keratinocytes (KC) with PHS can enhance the content of ceramide NP. It plays as key role in epidermal differentiation and also possesses anti-inflammatory and antimicrobial activities.

Embalagem

5 mL Amber Glass Screw Cap Vial (810314P-100ug)
5 mL Amber Glass Screw Cap Vial (810314P-250ug)
5 mL Amber Glass Screw Cap Vial (810314P-50ug)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

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Certificados de análise (COA)

Lot/Batch Number

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Visite a Biblioteca de Documentos

The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans
Munshi MA, et al.
Testing, 22(6), 1392-1400 (2018)
Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes
Choi HK, et al.
Lipids, 53(9), 909-918 (2018)
Phytosphingosine is a novel activator of GPR120
Nagasawa T, et al.
Test, 164(1), 27-32 (2018)
Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin
Kim S, et al.
Molecular Medicine, 12(1), 17-24 (2006)
Phytosphingosine enhances moisture level in human skin barrier through stimulation of the filaggrin biosynthesis and degradation leading to NMF formation
Choi H K, et al.
Archives of Dermatological Research, 309(10), 795-803 (2017)

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