920576

1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

• Sinônimo(s): Rigid linker for PROTAC^® development
• Fórmula empírica (Notação de Hill): C₁₃H₁₉N₃O₄
• Número CAS: 2095672-42-5
• Peso molecular: 281.31
• Número MDL: MFCD32649299
• Código UNSPSC: 12352106
• NACRES: NA.22

Propriedades

• forma: powder
• Nível de qualidade: 100
• adequação da reação: reagent type: linker
• grupo funcional: Boc; carboxylic acid
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CC(C)(OC(N1CC(C1)CN2C=C(C(O)=O)C=N2)=O)C

Descrição

Aplicação

1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920487
920495
920584
ADV638390284

Outras notas

Portal:Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable