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Merck
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Documentos

909866

Sigma-Aldrich

Poly(2-(dimethylamino)ethyl methacrylate)

average Mn 10,000

Sinônimo(s):

Hydrophilic polymer, PDMAEMA, pH sensitive, pH-responsive

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About This Item

Fórmula linear:
(C8H15NO2)n
Código UNSPSC:
12162002
NACRES:
NA.23

forma

powder or solid

peso molecular

average Mn 10,000 (by GPC)
average Mn 10,000

cor

white to faint yellow

PDI

≤1.4 (by GPC)

temperatura de armazenamento

2-8°C

Aplicação

Poly(2-(dimethylamino)ethyl methacrylate) is a pH-responsive polymer. pH-responsive polymers are a group of stimuli-responsive polymers that can respond to solution pH by undergoing structural and property changes such as surface activity, chain conformation, solubility, and configuration. The term “pH-responsive polymers” is commonly used to describe polymers having ionisable acidic or basic residues whose ionization depends on solution pH. The physical properties of the polymer, such as its chain conformation, configuration, and solubility, can be tailored by manipulating the pH or ionic strength. These unique properties of pH responsive polymer systems consequently make them very useful in various applications such as drug delivery, gene delivery, sensors, surfaces, membranes, and chromatography.
pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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pH-sensitive polymers for drug delivery
Huh K M,et al.
Macromolecular Research, 20(3), 224?233-224?233 (2012)
pH-Responsive polymers
Kocak G , et al.
Polym. Chem., 8, 144?176-144?176 (2017)
Jing Xie et al.
Macromolecular rapid communications, 38(23), 1499-1499 (2017-10-05)
Since diabetes mellitus has become one of the most serious threats to human health, researchers have been designing new drugs and developing new technologies to control the blood glucose level (BGL) while improving patient compliance. In addition to the traditional
Girish Kumar Tripathi et al.
Current drug delivery, 8(6), 667-677 (2012-02-09)
Helicobacter pylori reside in the gastric mucus layer and at the mucus-epithelial cell interface wherein access of antimicrobial drug to the infection site is restricted both from the stomach and from the gastric blood supply. The aim of the present
Themis R Kyriakides et al.
Journal of controlled release : official journal of the Controlled Release Society, 78(1-3), 295-303 (2002-01-05)
Cytosolic delivery from endosomes is critical for those drugs that are susceptible to attack by lysosomal enzymes, such as DNA, RNA, oligonucleotides, proteins and peptides. Therefore, we have designed pH-sensitive, membrane-disruptive polymers to enhance the release of drugs from the
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