906298

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

• Sinônimo(s): Probe building block for photoaffinity labeling, Suzuki-Miyaura-compatible multifunctional photo probe building block, Trifluoromethyl diazirine aryl bromide
• Fórmula empírica (Notação de Hill): C₈H₄BrF₃N₂
• Número CAS: 952143-02-1
• Peso molecular: 265.03
• Número MDL: MFCD31667367
• Código UNSPSC: 12352101
• NACRES: NA.22

Propriedades

• Ensaio: ≥95%
• Formulário: liquid
• adequação da reação: reagent type: cross-linking reagent
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: BrC1=CC=C(C2(N=N2)C(F)(F)F)C=C1
• InChI: 1S/C8H4BrF3N2/c9-6-3-1-5(2-4-6)7(13-14-7)8(10,11)12/h1-4H
• chave InChI: YBEXZCGWGWNLQQ-UHFFFAOYSA-N

Descrição

Aplicação

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Outras notas

Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable