671274

(R,R)-(−)-N,N′-Dimethyl-1,2-cyclohexanediamine

≥97.0% (GC)

• Sinônimo(s): (R,R)-(−)-N,N′-Dimethyl-1,2-diaminocyclohexane, trans-1,2-Bis(methylamino)cyclohexane
• Fórmula empírica (Notação de Hill): C₈H₁₈N₂
• Número CAS: 68737-65-5
• Peso molecular: 142.24
• Número MDL: MFCD00671527
• Código UNSPSC: 12352116
• ID de substância PubChem: 24885095
• NACRES: NA.22

Propriedades

• Ensaio: ≥97.0% (GC)
• atividade óptica: [α]/D -145±5°, c = 4.47 in chloroform
• pf: 39-44 °C
• grupo funcional: amine
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CN[C@@H]1CCCC[C@H]1NC
• InChI: 1S/C8H18N2/c1-9-7-5-3-4-6-8(7)10-2/h7-10H,3-6H2,1-2H3/t7-,8-/m1/s1
• chave InChI: JRHPOFJADXHYBR-HTQZYQBOSA-N

Descrição

Descrição geral

(R,R)-(-)-N,N′-Dimethyl-1,2-cyclohexanediamine is a N,N′-dimethylated derivative of enantiopure 1,2-diaminocyclohexane. It can be formed during the hydrolysis of (R_3a,R_7a)-1,3-(dimethyl)-2-phenyl-2,3,3a,4,5,6,7,7a-octahydro-1H-1,3,2-benzodiazaphosphole 2-oxide using HCl-methanol.[1]

Aplicação

(R,R)-(−)-N,N′-Dimethyl-1,2-cyclohexanediamine can be used:

• As a ligand in the preparation of 4H-benzo[f]imidazo[1,4]diazepin-6-one through multi-component Ullmann coupling reaction.[2]
• In one of the key synthetic steps for the preparation of tricyclic γ-secretase modulators.[3]
• To prepare chiral fluorous diamino-diol proligand, which is used in the synthesis of zirconium metal complexes applicable as catalysts in 1-hexene polymerization.[4]

Informações de segurança

• Pictogramas: GHS05,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H314
• Declarações de precaução: P270 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Código de classe de armazenamento: 8A - Combustible corrosive hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 165.2 °F - closed cup
• Ponto de fulgor (°C): 74 °C - closed cup
• Equipamento de proteção individual: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter