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56485

Sigma-Aldrich

N-hidroxissulfosuccinimida

≥98% (HPLC), for peptide synthesis

Sinônimo(s):

Sulfo-NHS, Ácido hidroxi-2,5-dioxopirrolidina-3-sulfônico

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About This Item

Fórmula empírica (Notação de Hill):
C4H4NNaO6S
Número CAS:
106627-54-7
Peso molecular:
217.13
Beilstein:
6359129
Número MDL:
MFCD00043100
Código UNSPSC:
12352005
ID de substância PubChem:
57651582
NACRES:
NA.22
Preço e disponibilidade não estão disponíveis no momento.

Nome do produto

N-hidroxissulfosuccinimida, ≥98% (HPLC)

Nível de qualidade

200

Ensaio

≥98% (HPLC)

Formulário

powder

composição

carbon, 21.57-22.68 (anhydrous)
nitrogen, 6.28-6.61 (anhydrous)

adequação da reação

reaction type: Addition Reactions

Impurezas

≤4% water

aplicação(ões)

peptide synthesis

grupo funcional

imide
sulfonic acid

cadeia de caracteres SMILES

[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O

InChI

1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1

chave InChI

RPENMORRBUTCPR-UHFFFAOYSA-M

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Categorias relacionadas

Aplicação

O sal sódico de N-hidroxissulfosuccinimida é um análogo sulfonado solúvel em água da N-hidroxissuccinimida. Ela pode sofrer uma reação de acoplamento com ácidos carboxílicos na presença de carbodiimidas, como 1-etil-3-(3-dimetilaminopropil)carbodiimida (EDC) para formar ésteres ativos de N-hidroxissulfosuccinimida hidrofílicos. Esses ésteres são úteis em experimentos de reticulação de proteínas.[1][2]

Embalagem

Frasco de vidro sem fundo. O conteúdo fica dentro de um cone fundido.

Outras notas

A sulfo-NHS é usada para preparar ésteres ativos hidrofílicos, como para agentes reticulantes[3][4]

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCCM3588
BCCL3044
BCCJ9858
WXBF1499V
WXBF0098V

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N-hydroxysulfosuccinimide active esters: bis (N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers.
Staros JV
Biochemistry, 21(17), 3950-3955 (1982)
Xiao-Yan Xu et al.
Journal of materials chemistry. B, 7(32), 4963-4972 (2019-08-15)
The construction of antibacterial and antitumor coatings could offer effective routes to improve the therapeutic effects of non-vascular stents for unresectable obstructions caused by malignant tumours. Herein, polyelectrolyte multilayers have been explored as bactericidal coatings with controlled antitumor drug release.
R Maydelid Trujillo-Nolasco et al.
Materials science & engineering. C, Materials for biological applications, 103, 109766-109766 (2019-07-28)
Radiosynovectomy is a technique used to decrease inflammation of the synovial tissue by intraarticular injection of a β-emitting radionuclide, such as 177Lu, which is suitable for radiotherapy due to its decay characteristics. Drug-encapsulating nanoparticles based on poly lactic‑co‑glycolic acid (PLGA)
P S Anjaneyulu et al.
International journal of peptide and protein research, 30(1), 117-124 (1987-07-01)
N-Hydroxysulfosuccinimide esters are reactive functional groups employed in a variety of protein modification reagents, especially cross-linking reagents. For these compounds, hydrolysis is the most important reaction competing for reaction of the esters with nucleophilic groups in proteins. We have employed
Eloy Povedano et al.
Scientific reports, 8(1), 6418-6418 (2018-04-25)
This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What are the storage conditions for product 56485? There are no recommended conditions. Is it Room temp?

    1 answer

    1. As mentioned in the Material Safery Data Sheet, section 7, it is recommended to store under inert gas such as argon or nitrogen. Please see the link below to review the SDS:
      https://www.sigmaaldrich.com/sds/aldrich/56485

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