About This Item
Fórmula empírica (Notação de Hill):
C10H9NO2
Número CAS:
Peso molecular:
175.18
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
Produtos recomendados
Nível de qualidade
Ensaio
97%
pf
197-200 °C (dec.) (lit.)
grupo funcional
carboxylic acid
cadeia de caracteres SMILES
Cn1cc(C(O)=O)c2ccccc12
InChI
1S/C10H9NO2/c1-11-6-8(10(12)13)7-4-2-3-5-9(7)11/h2-6H,1H3,(H,12,13)
chave InChI
HVRCLXXJIQTXHC-UHFFFAOYSA-N
Descrição geral
1-Methylindole-3-carboxylic acid is an indole derivative that can be prepared by the oxidation of 1-methylindole-3-aldehyde with alkaline potassium permanganate.
Aplicação
- Reactant for preparation of bisindolyl pyrimidinones analogs of PKC inhibitor LY333531
- Reactant for preparation of (heteroaryl)(carboxamido)arylpyrrole derivatives as Cdc7 kinase inhibitors, antitumor and antiproliferative agents
- Reactant for preparation of (pyrrolidinylmethoxy)cyclohexanecarboxylic acids as antigen-4 (VLA-4) antagonists
- Reactant for preparation of EphB3 receptor tyrosine kinase inhibitors
- Reactant for preparation of pyrazolodiazepine derivatives as human P2X7 receptor antagonists
- Reactant for preparation of potent nonpeptidic urotensin II receptor agonists
- Reactant for preparation of pyrrolizidine esters, amides, and ureas as 5-HT4 receptor ligands
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órgãos-alvo
Respiratory system
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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Desulfurization of Thiiranes with Iodine.
Helmkamp GK and Pettitt DJ.
The Journal of Organic Chemistry, 27(80, 2942-2943 (1962)
Reaction of Some Indole Ketones with Iodine and Pyridine.
Hart G and Potts KT.
The Journal of Organic Chemistry, 27(8), 2940-2942 (1962)
Mitra Shokrollahi et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 31(10), e13598-e13598 (2019-04-24)
Activating luminal 5-HT4 receptors results in the release of 5-HT from enterochromaffin cells into the lamina propria to modulate colonic motility. Our aim was to evaluate characteristics of colonic motor patterns involved in the prokinetic effects of intraluminal prucalopride in
Yuan Guo et al.
Neuropsychobiology, 80(1), 52-63 (2020-07-15)
The 5-hydroxytryptamine (5-HT) neurotransmitter system and lateral habenula (LHb) are involved in the regulation of depression, while the mechanisms remain to be clarified. The effects and possible mecha-nism underlying activation or blockade of 5-HT4 receptors (5-HT4Rs) in the LHb in
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