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334642

Sigma-Aldrich

Bis(cyclopentadienyl)vanadium(IV) dichloride

95%

Sinônimo(s):

Di-π-Cyclopentadienylvanadium dichloride, Dichlorobis(cyclopentadienyl)vanadium, Dichlorovanadocene, Vanadocene dichloride

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About This Item

Fórmula empírica (Notação de Hill):
C10H10Cl2V
Número CAS:
12083-48-6
Peso molecular:
252.03
Número CE:
235-150-8
Número MDL:
MFCD00014260
Código UNSPSC:
12352300
ID de substância PubChem:
24860247

Ensaio

95%

forma

solid

adequação da reação

core: vanadium
reagent type: catalyst

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl[V]Cl.[CH]1[CH][CH][CH][CH]1.[CH]2[CH][CH][CH][CH]2

InChI

1S/2C5H5.2ClH.V/c2*1-2-4-5-3-1;;;/h2*1-5H;2*1H;/q;;;;+2/p-2

chave InChI

MDWJZZZKWHLMQP-UHFFFAOYSA-L

Aplicação

Uses:
  • Potential pharmacological compound for cancer treatment
  • Catalyst for solvent free, room temperature preparation of vicinal aminoalcohols as fungistatic agents
  • Catalyst fot oligomerization reactions via the Aufbau propagation reaction
  • Catalyst for aqueous polymerization reactions using oxygen as a cocatalyst
  • Catalyst for dl-selective pinacol-type coupling reactions
  • Affector of crystal growth of calcium carbonate
  • Inhibitor of human topoisomerase II enzyme with antitumor activity

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301,H315,H319,H335

Classificações de perigo

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
MKBV5933V
MKBR4487V
MKBN8741V
MKBK6123V
MKBD4266

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Radim Havelek et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 8(4), 615-621 (2012-04-26)
Modern chemotherapy is interested in developing new agents with high efficiency of treatment in low-dose medication strategies, lower side toxicity and stronger specificity to the tumor cells. Vanadocene dichloride (VDC) belongs to the group of the most promising metallocene antitumor
P Köpf-Maier et al.
Chemico-biological interactions, 44(3), 317-328 (1983-06-01)
The intracellular distribution patterns of the metal atoms titanium and vanadium after in vivo as well as in vitro treatment of Ehrlich ascites tumor with the antitumor agents titanocene dichloride (TDC) or vanadocene dichloride (VDC) have been investigated by use
P Köpf-Maier
Journal of cancer research and clinical oncology, 103(2), 145-164 (1982-01-01)
Light-microscopic and ultrastructural alteration patterns are investigated after in vivo treatment of EAT with the cytostatic agents VDC and TC. Both substances induce mitotic aberrations, e.g., pyknotic metaphases, lagging chromosomes during anaphase, and multipolar mitotic figures. The appearance of mononucleate
J H Toney et al.
Chemico-biological interactions, 56(1), 45-54 (1985-12-17)
The biodistribution and pharmacokinetics of vanadium following i.p. administration of vanadocene dichloride (VDC), a representative of a new class of organometallic anticancer agents, is reported for Strain A mice. A convenient flameless atomic absorption spectroscopic assay is described and is
O J D'Cruz et al.
Biology of reproduction, 58(6), 1515-1526 (1998-06-12)
We have used computer-assisted sperm analysis (CASA) to evaluate the spermicidal activity of 8 metallocene dihalides (vanadocene dichloride [VDC], titanocene dichloride [TDC], zirconocene dichloride [ZDC], molybdocene dichloride [MDC], hafnocene dichloride [HDC], vanadocene dibromide [VDB], bis[methylcyclopentadienyl] vanadium dichloride [VMDC], and vanadocene
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