218707
Cyclophosphamide monohydrate
≥98%
Sinônimo(s):
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
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About This Item
Fórmula empírica (Notação de Hill):
C7H15Cl2N2O2P · H2O
Número CAS:
Peso molecular:
279.10
Beilstein:
4678992
Número CE:
Número MDL:
Código UNSPSC:
12352103
Produtos recomendados
Ensaio
≥98%
pf
49-51 °C (lit.)
cadeia de caracteres SMILES
[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
InChI
1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
chave InChI
PWOQRKCAHTVFLB-UHFFFAOYSA-N
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Ações bioquímicas/fisiológicas
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.
Características e benefícios
Cancer research tool.
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 105, 278-284 (2017-04-30)
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Karen Gomez-Mariscal et al.
Annals of clinical and laboratory science, 48(2), 152-157 (2018-04-22)
The aim of the study was to determine if amniotic fluid cells of rats can be used to provide evidence of genotoxicity. In order to do that micronuclei formation was induced in rats during pregnancy after treatment with cyclophosphamide (CP)
S Khan et al.
Toxicology international, 20(1), 68-76 (2013-07-09)
Recently, sodium valproate (VPA) has been proven as histone deacetylase (HDAC) inhibitor and potentiates the cytotoxicity of anticancer drugs, and also exhibit promising anti-cancer activity. Present study aimed to investigate the influence of pre- and post-treatment of VPA on cyclophosphamide
Lisanne Grenier et al.
Toxicological sciences : an official journal of the Society of Toxicology, 127(2), 555-566 (2012-03-29)
Male germ cell DNA damage, after exposure to radiation, exogenous chemicals, or chemotherapeutic agents, is a major cause of male infertility. DNA-damaged spermatozoa can fertilize oocytes; this is of concern because there is limited information on the capacity of early
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