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Merck

THRB

thyroid hormone receptor, beta

Sinônimos:
C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
Espécies:
ID UniProtKB:
ID do gene:
  • Human(7068) Summary: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(21834) thyroid hormone receptor beta
  • Rat(24831) thyroid hormone receptor beta
  • Domestic Rabbit(100303763) thyroid hormone receptor, beta
  • chicken(396431) thyroid hormone receptor, beta
  • cow(788329) thyroid hormone receptor, beta
  • domestic cat(101084821) thyroid hormone receptor, beta
  • Horse(100051615) thyroid hormone receptor, beta
  • dog(403599) thyroid hormone receptor, beta
  • naked mole-rat(101719651) thyroid hormone receptor, beta
  • domestic guinea pig(100721125) thyroid hormone receptor, beta
  • Zebrafish(30607) thyroid hormone receptor beta

Custom & Knockdown Gene Products

Small Molecule - Agonist

Número do produto
Descrição
Espécies
3,3′,5-Triiodo-L-thyronine (T3) solution, 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®,
Espécies
human
Levothyroxine, Pharmaceutical Secondary Standard; Certified Reference Material,
Espécies
human
L-Thyroxine (T4) solution, 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®,
Espécies
human
Liothyronine, Pharmaceutical Secondary Standard; Certified Reference Material,
Espécies
human
Levothyroxine sodium, European Pharmacopoeia (EP) Reference Standard,
Espécies
human

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
3,3′,5-Triiodo-L-thyronine sodium salt, powder, BioReagent, suitable for cell culture,
Espécies
rat, human
3,3′,5-Triiodo-L-thyronine, ≥95% (HPLC), powder,
Espécies
rat, human
3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, suitable for, suitable for cell culture,
Espécies
rat, human
3,3′,5-Triiodothyroacetic acid, ≥90%,
Espécies
rat, human
3,3′,5-Triiodo-L-thyronine sodium salt, ≥95% (HPLC),
Espécies
rat, human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Thyroid Hormone Receptor β, N-Terminal antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunohistochemistry

western blot
Anti-THRB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
immunofluorescence
Anti-Thyroid Hormone Receptor β-1 Antibody, from rabbit, purified by affinity chromatography,
Reatividade de espécies
human, mouse, rat
Aplicação
western blot
Anti-phospho-TR-β1 (pSer142) antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
western blot

Small Molecule - Blocker

Número do produto
Descrição
Espécies
3,3′,5-Triiodo-L-thyronine sodium salt, powder, BioReagent, suitable for cell culture,
Espécies
rat, human
3,3′,5-Triiodo-L-thyronine, ≥95% (HPLC), powder,
Espécies
rat, human
3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, suitable for, suitable for cell culture,
Espécies
rat, human
3,3′,5-Triiodo-L-thyronine sodium salt, ≥95% (HPLC),
Espécies
rat, human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human THRB,
Espécies
human