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K1751

Sigma-Aldrich

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

Synonyme(s) :

2-(3-Benzoylphenyl)propionic acid

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About This Item

Formule empirique (notation de Hill):
C16H14O3
Numéro CAS:
22071-15-4
Poids moléculaire :
254.28
Numéro CE :
244-759-8
Numéro MDL:
MFCD00055790
Code UNSPSC :
12352200
ID de substance PubChem :
57654315
Nomenclature NACRES :
NA.77

product name

Ketoprofen, ≥98% (TLC)

Source biologique

synthetic

Pureté

≥98% (TLC)

Forme

powder

Solubilité

ethanol: 50 mg/mL, clear, colorless to yellow

Auteur

Bayer

Chaîne SMILES 

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

Clé InChI

DKYWVDODHFEZIM-UHFFFAOYSA-N

Informations sur le gène

human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

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Description générale

Ketoprofen belongs to the class of 2-arylpropionic acid.

Application

Ketoprofen has been used:
  • as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
  • as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
  • in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Actions biochimiques/physiologiques

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.
Composé anti-inflammatoire non stéroïdien spécifique de la COX-1.

Caractéristiques et avantages

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Skull and crossbonesEnvironment
GHS06,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301,H315,H319,H400

Classification des risques

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ekaterina Blinova et al.
Biomolecules, 11(6) (2021-07-03)
The main goal of our study was to explore the wound-healing property of a novel cerium-containing N-acethyl-6-aminohexanoate acid compound and determine key molecular targets of the compound mode of action in diabetic animals. Cerium N-acetyl-6-aminohexanoate (laboratory name LHT-8-17) as a
Polyamidoamine dendrimers used as solubility enhancers of ketoprofen
Yiyun C, et al.
European Journal of Medicinal Chemistry, 40(12), 1390-1393 (2005)
In vitro chiral conversion, phase separation, and wave propagation in aged profen solutions
Sajewicz M, et al.
Journal of Liquid Chromatography and Related Technologies, 32(9), 1359-1372 (2009)
Ekaterina Blinova et al.
International journal of molecular sciences, 22(18) (2021-09-29)
The possible involvement of p53 signaling, FGFR3 expression, and FGFR3 mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 expression, FGFR3
L Saso et al.
Archives of pharmacal research, 24(2), 150-158 (2001-05-08)
The activity of nonsteroidal antiinflammatory drugs (NSAIDs) in rheumatoid arthritis is not only due to the inhibition of the production of prostaglandins, which can even have beneficial immunosuppressive effects in chronic inflammatory processes. Since we speculated that these drugs could
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Chromatograms

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