676377

Valinomycin, Streptomyces fulvissimus

A cyclododecadepsi-peptide ionophore antibiotic.

• Synonyme(s) : Valinomycin, Streptomyces fulvissimus
• Formule empirique (notation de Hill): C₅₄H₉₀N₆O₁₈
• Numéro CAS: 2001-95-8
• Poids moléculaire : 1111.32
• Numéro MDL: MFCD00005114
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 200
• Essai: ≥93% (HPLC)
• Forme: crystalline solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: DMSO: soluble; acetic acid: soluble; chloroform: soluble; ether: soluble
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36?,37-,38-,39-,40+,41+,42+/m0/s1
• Clé InChI: FCFNRCROJUBPLU-UYBNATROSA-N

Description

Description générale

A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb⁺ >K⁺ >Cs⁺ >Ag⁺ >NH₄⁺ >Na⁺ >Li⁺). Induces K⁺ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K⁺ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K⁺ concentration. Useful in studies of K⁺ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
NGF-induced neuronal differentiation

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Highly Toxic (H)

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Harada, H., et al. 1994. Biochim. Biophys. Acta1220, 310.
Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
Orlov, V.N., et al. 1994. FEBS Lett.345, 104.
Acra, S., et al. 1993. Am. J. Physiol.264, G45.
Cornet, M., et al. 1993. J. Membr. Biol.131, 55.
Deckers, C.L., et al. 1993. Exp. Cell Res.208, 362.
Dimroth, P., and Thomer, A. 1993. Biochemistry32, 1734.
Opanasenko, V.K., et al. 1992. FEBS Lett.307, 280.
Pape, P.C., et al. 1992. J. Physiol.449, 219.
Ahmed, S., and Booth, I.R. 1983. Biochem. J.212, 105.
Lerner, A., et al. 1982. FEBS Lett.146, 9.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300 + H310
• Conseils de prudence: P262 - P264 - P280 - P301 + P310 - P302 + P352 + P310 - P361 + P364
• Classification des risques: Acute Tox. 1 Dermal - Acute Tox. 1 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable