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WH0004041M1

Sigma-Aldrich

Monoclonal Anti-LRP5 antibody produced in mouse

clone 1E9, purified immunoglobulin, buffered aqueous solution

Synonym(e):

Anti-BMND1, Anti-HBM, Anti-LR3, Anti-LRP7, Anti-OPPG, Anti-OPS, Anti-VBCH2, Anti-low density lipoprotein receptor-related protein 5

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

1E9, monoclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Methode(n)

ELISA: suitable
western blot: 1-5 μg/mL

Isotyp

IgG1κ

GenBank-Hinterlegungsnummer

NM_002335

UniProt-Hinterlegungsnummer

O75197

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... LRP5(4041)

Allgemeine Beschreibung

Low-density lipoprotein receptor-related protein 5 or LRP5 functions as a co-receptor for the Wnt signaling complex. LRP5 is involved in various processes such as bone mass regulation, pulmonary angiogenesis, and alveolar synthesis . Monoclonal Anti-LRP5 antibody is specific for LRP5 in humans.

Immunogen

LRP5 (NP_002326.1, 41 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
RDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETN

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Rechtliche Hinweise

GenBank is a registered trademark of United States Department of Health and Human Services

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Tadanori Mammoto et al.
PloS one, 7(7), e41596-e41596 (2012-08-01)
Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood. Here we show that low-density lipoprotein receptor-related protein 5 (LRP5), a component
Yajun Cui et al.
Nature medicine, 17(6), 684-691 (2011-05-24)
The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with osteocyte-specific expression of inducible Lrp5 mutations that cause high and low bone mass phenotypes in

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